In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells

The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. This work deals with in silico and in vitro studies of one clioquinol oxidovanadium(IV) complex [VO(clioquinol)2], VO(C...

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Autores principales: Balsa, Lucía Mariana, Quispe Castillo, Patricia Araceli, Baran, Enrique José, Lavecchia, Martín José, León, Ignacio Esteban
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2020
Materias:
Salud
Química
vanadium compounds
human osteosarcoma cancer cells
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/134045
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-134045
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spelling I19-R120-10915-1340452024-11-13T18:17:12Z http://sedici.unlp.edu.ar/handle/10915/134045 In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells Balsa, Lucía Mariana Quispe Castillo, Patricia Araceli Baran, Enrique José Lavecchia, Martín José León, Ignacio Esteban 2020-12-23 2022-04-06T19:11:28Z en Salud Química vanadium compounds human osteosarcoma cancer cells The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. This work deals with in silico and in vitro studies of one clioquinol oxidovanadium(IV) complex [VO(clioquinol)2], VO(CQ)2, and its regulation of FAK. In particular, we focus on elucidating the relationship of the FAK inhibition, MMP activity and antimetastatic effects of the complex in human bone cancer cells. Centro de Química Inorgánica Articulo Preprint http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf 1931-1940
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Salud
Química
vanadium compounds
human osteosarcoma cancer cells
spellingShingle Salud
Química
vanadium compounds
human osteosarcoma cancer cells
Balsa, Lucía Mariana
Quispe Castillo, Patricia Araceli
Baran, Enrique José
Lavecchia, Martín José
León, Ignacio Esteban
In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells
topic_facet Salud
Química
vanadium compounds
human osteosarcoma cancer cells
description The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. This work deals with in silico and in vitro studies of one clioquinol oxidovanadium(IV) complex [VO(clioquinol)2], VO(CQ)2, and its regulation of FAK. In particular, we focus on elucidating the relationship of the FAK inhibition, MMP activity and antimetastatic effects of the complex in human bone cancer cells.
format Articulo
Preprint
author Balsa, Lucía Mariana
Quispe Castillo, Patricia Araceli
Baran, Enrique José
Lavecchia, Martín José
León, Ignacio Esteban
author_facet Balsa, Lucía Mariana
Quispe Castillo, Patricia Araceli
Baran, Enrique José
Lavecchia, Martín José
León, Ignacio Esteban
author_sort Balsa, Lucía Mariana
title In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells
title_short In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells
title_full In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells
title_fullStr In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells
title_full_unstemmed In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells
title_sort in silico and in vitro analysis of fak/mmp signaling axis inhibition by vo-clioquinol in 2d and 3d human osteosarcoma cancer cells
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/134045
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