DNA damage exerted by mixtures of commercial formulations of glyphosate and imazethapyr herbicides in Rhinella arenarum (Anura, Bufonidae) tadpoles

Glyphosate (GLY) and imazethapyr (IMZT) are two herbicides commonly used worldwide, either alone or in mixtures. They represent key pesticides in modern agricultural management. The toxicity that results when employed as mixtures has not been characterized so far. Acute toxicity of the 48% GLY-based...

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Autores principales: Fernandes Carvalho, Wanessa, Ruiz de Arcaute, Celeste, Pérez Iglesias, Juan Manuel, Laborde, Milagros, Soloneski, Sonia María Elsa, Larramendy, Marcelo Luis
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Química
Amphibians
Comet assay
Credit®
Herbicide binary mixture
Pivot® H
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/133684
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-133684
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Amphibians
Comet assay
Credit®
Herbicide binary mixture
Pivot® H
spellingShingle Química
Amphibians
Comet assay
Credit®
Herbicide binary mixture
Pivot® H
Fernandes Carvalho, Wanessa
Ruiz de Arcaute, Celeste
Pérez Iglesias, Juan Manuel
Laborde, Milagros
Soloneski, Sonia María Elsa
Larramendy, Marcelo Luis
DNA damage exerted by mixtures of commercial formulations of glyphosate and imazethapyr herbicides in Rhinella arenarum (Anura, Bufonidae) tadpoles
topic_facet Química
Amphibians
Comet assay
Credit®
Herbicide binary mixture
Pivot® H
description Glyphosate (GLY) and imazethapyr (IMZT) are two herbicides commonly used worldwide, either alone or in mixtures. They represent key pesticides in modern agricultural management. The toxicity that results when employed as mixtures has not been characterized so far. Acute toxicity of the 48% GLY-based herbicide (GBH) Credit<sup>®</sup> and the 10.59% IMZT-based herbicide (IBH) Pivot<sup>®</sup> H alone and their binary combinations was analyzed in Rhinella arenarum tadpoles exposed in a semi-static renewal test. Lethal effects were determined using mortality as the end-point, whereas sublethal effects were determined employing the single-cell gel electrophoresis (SCGE) bioassay. Based on mortality experiments, results revealed LC50<sub>96 h</sub> values of 78.18 mg/L GBH and 0.99 mg/L IBH for Credit<sup>®</sup> and Pivot<sup>®</sup> H, respectively. An increase in the genetic damage index (GDI) was found after exposure to Credit<sup>®</sup> or Pivot<sup>®</sup> H at 5 and 10% of LC50<sub>96 h</sub> values. The combinations of 5% Credit<sup>®</sup>-5% Pivot<sup>®</sup> H LC50<sub>96 h</sub> and 10% Credit<sup>®</sup>-10% Pivot<sup>®</sup> H LC50<sub>96 h</sub> concentrations significantly enhanced the GDI in comparison with tadpoles exposed only to Credit<sup>®</sup> or Pivot<sup>®</sup> H. Thus, the effect of interaction between GBH and IBH inducing DNA damage in R. arenarum blood cells can be considered to be synergistic.
format Articulo
Articulo
author Fernandes Carvalho, Wanessa
Ruiz de Arcaute, Celeste
Pérez Iglesias, Juan Manuel
Laborde, Milagros
Soloneski, Sonia María Elsa
Larramendy, Marcelo Luis
author_facet Fernandes Carvalho, Wanessa
Ruiz de Arcaute, Celeste
Pérez Iglesias, Juan Manuel
Laborde, Milagros
Soloneski, Sonia María Elsa
Larramendy, Marcelo Luis
author_sort Fernandes Carvalho, Wanessa
title DNA damage exerted by mixtures of commercial formulations of glyphosate and imazethapyr herbicides in Rhinella arenarum (Anura, Bufonidae) tadpoles
title_short DNA damage exerted by mixtures of commercial formulations of glyphosate and imazethapyr herbicides in Rhinella arenarum (Anura, Bufonidae) tadpoles
title_full DNA damage exerted by mixtures of commercial formulations of glyphosate and imazethapyr herbicides in Rhinella arenarum (Anura, Bufonidae) tadpoles
title_fullStr DNA damage exerted by mixtures of commercial formulations of glyphosate and imazethapyr herbicides in Rhinella arenarum (Anura, Bufonidae) tadpoles
title_full_unstemmed DNA damage exerted by mixtures of commercial formulations of glyphosate and imazethapyr herbicides in Rhinella arenarum (Anura, Bufonidae) tadpoles
title_sort dna damage exerted by mixtures of commercial formulations of glyphosate and imazethapyr herbicides in rhinella arenarum (anura, bufonidae) tadpoles
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/133684
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