Is violet LED light efficient to treat superficial lesions such as a low-grade cervical intraepithelial neoplasia?

Photosensitizers utilized in photodynamic therapy (PDT) can be exited with light of any wavelengths matching their absorption bands. Thus, superficial lesions, such as those involved in cervical intraepithelial neoplasias (CINs) might be treated with a light of shorter wavelength than red despite th...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Etcheverry, María Eugenia, Pasquale, Miguel Ángel, Garavaglia, Mario José
Formato: Objeto de conferencia
Lenguaje:Inglés
Publicado: 2021
Materias:
Física
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/133623
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-133623
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Física
spellingShingle Física
Etcheverry, María Eugenia
Pasquale, Miguel Ángel
Garavaglia, Mario José
Is violet LED light efficient to treat superficial lesions such as a low-grade cervical intraepithelial neoplasia?
topic_facet Física
description Photosensitizers utilized in photodynamic therapy (PDT) can be exited with light of any wavelengths matching their absorption bands. Thus, superficial lesions, such as those involved in cervical intraepithelial neoplasias (CINs) might be treated with a light of shorter wavelength than red despite the smaller penetration depth in tissue. We review basic aspects of PDT and some investigations related to the use of light-emitting diodes (LEDs) of different wavelength mainly applied to superficial lesions, and highlight the benefits of the use of violet light and cellular spheroids as a PDT dosage model. Our previous results from spheroids of cervix carcinoma cells, suggest that the violet light from a LED source is appropriate for performing PDT of neoplastic lesions involving about 300 μm in depth. In this work we present a high fluence light source emitting at 420 nm and apply it to perform PDT treatment of a HeLa cell tumor model implanted in BALB/c nude mice. The photodynamic reaction is inferred from the fluorescence evolution measured at the tumor and the temperature evolution of the treated surface. Violet LED light could be a promising alternative for treating CINs involving superficial dysplasia, with reduced side effects.
format Objeto de conferencia
Objeto de conferencia
author Etcheverry, María Eugenia
Pasquale, Miguel Ángel
Garavaglia, Mario José
author_facet Etcheverry, María Eugenia
Pasquale, Miguel Ángel
Garavaglia, Mario José
author_sort Etcheverry, María Eugenia
title Is violet LED light efficient to treat superficial lesions such as a low-grade cervical intraepithelial neoplasia?
title_short Is violet LED light efficient to treat superficial lesions such as a low-grade cervical intraepithelial neoplasia?
title_full Is violet LED light efficient to treat superficial lesions such as a low-grade cervical intraepithelial neoplasia?
title_fullStr Is violet LED light efficient to treat superficial lesions such as a low-grade cervical intraepithelial neoplasia?
title_full_unstemmed Is violet LED light efficient to treat superficial lesions such as a low-grade cervical intraepithelial neoplasia?
title_sort is violet led light efficient to treat superficial lesions such as a low-grade cervical intraepithelial neoplasia?
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/133623
work_keys_str_mv AT etcheverrymariaeugenia isvioletledlightefficienttotreatsuperficiallesionssuchasalowgradecervicalintraepithelialneoplasia
AT pasqualemiguelangel isvioletledlightefficienttotreatsuperficiallesionssuchasalowgradecervicalintraepithelialneoplasia
AT garavagliamariojose isvioletledlightefficienttotreatsuperficiallesionssuchasalowgradecervicalintraepithelialneoplasia
bdutipo_str Repositorios
_version_ 1764820455103922176

Ejemplares similares