Studies of Ciprofloxacin Encapsulation on Alginate/Pectin Matrixes and Its Relationship with Biodisponibility

Screening of ciprofloxacin (Cip) with selected biopolymers brings about 90% antibiotic interactions with a coacervate composed of alginate/high metoxylated pectin in 2:1 ratio. Fourier transform infrared spectroscopy analysis provides information about the nature of this interaction, revealing ionic...

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Autores principales: Islan, Germán Abel, Pérez de Berti, Ignacio Omar, Marchetti, Sergio Gustavo, Castro, Guillermo Raúl
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Ciencias Exactas
Biología
Pectin
Alginate
Biopolymer blends
Ciprofloxacin
Controlled release
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/133593
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-133593
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Biología
Pectin
Alginate
Biopolymer blends
Ciprofloxacin
Controlled release
spellingShingle Ciencias Exactas
Biología
Pectin
Alginate
Biopolymer blends
Ciprofloxacin
Controlled release
Islan, Germán Abel
Pérez de Berti, Ignacio Omar
Marchetti, Sergio Gustavo
Castro, Guillermo Raúl
Studies of Ciprofloxacin Encapsulation on Alginate/Pectin Matrixes and Its Relationship with Biodisponibility
topic_facet Ciencias Exactas
Biología
Pectin
Alginate
Biopolymer blends
Ciprofloxacin
Controlled release
description Screening of ciprofloxacin (Cip) with selected biopolymers brings about 90% antibiotic interactions with a coacervate composed of alginate/high metoxylated pectin in 2:1 ratio. Fourier transform infrared spectroscopy analysis provides information about the nature of this interaction, revealing ionic and hydrophobic patterns among the molecules. Alginate/high methoxylated pectin gel microspheres developed by ionic gelation encapsulates 46.8 ± 5.0% Cip. The gel matrix can release Cip in a sustained manner, releasing 42.7 ± 0.2% in 2 h under simulated stomach pH conditions, and 83.3 ± 1.1% Cip release in 80 mM phosphate at pH = 7.40 (intestinal). The increase of sodium chloride from 50 to 200 mM implies a Cip release from 69.0 ± 1.5% to 95.1 ± 3.6% respectively in 2 h. Scanning electron microscopy revealed the cohesive effect of HM pectin over alginate molecules on the microsphere surface. Those results guarantee all Cip contained in the alginate/HM pectin microspheres could be released in an established kinetic profile along the gastrointestinal tract, avoiding the Cip undesirable side effects during absorption.
format Articulo
Articulo
author Islan, Germán Abel
Pérez de Berti, Ignacio Omar
Marchetti, Sergio Gustavo
Castro, Guillermo Raúl
author_facet Islan, Germán Abel
Pérez de Berti, Ignacio Omar
Marchetti, Sergio Gustavo
Castro, Guillermo Raúl
author_sort Islan, Germán Abel
title Studies of Ciprofloxacin Encapsulation on Alginate/Pectin Matrixes and Its Relationship with Biodisponibility
title_short Studies of Ciprofloxacin Encapsulation on Alginate/Pectin Matrixes and Its Relationship with Biodisponibility
title_full Studies of Ciprofloxacin Encapsulation on Alginate/Pectin Matrixes and Its Relationship with Biodisponibility
title_fullStr Studies of Ciprofloxacin Encapsulation on Alginate/Pectin Matrixes and Its Relationship with Biodisponibility
title_full_unstemmed Studies of Ciprofloxacin Encapsulation on Alginate/Pectin Matrixes and Its Relationship with Biodisponibility
title_sort studies of ciprofloxacin encapsulation on alginate/pectin matrixes and its relationship with biodisponibility
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/133593
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