Estrategias de control avanzadas para páncreas artificial

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Artificial Pancreas (AP) systems consist on a subcutaneous insulin pump connected to a continuous glucose monitor (CGM) through a control algorithm that calculates the appropriate insulin dose according to CGM readings. Though great research has been carried in this topic, there are still many limit...

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Autor principal: Fushimi, Emilia
Otros Autores: Garelli, Fabricio
Formato: Tesis Tesis de doctorado
Lenguaje:Español
Publicado: 2021
Materias:
Ingeniería
Diabetes Mellitus Tipo 1
Páncreas Artificial
Control Automático
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/133534
https://doi.org/10.35537/10915/133534
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-133534
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ingeniería
Diabetes Mellitus Tipo 1
Páncreas Artificial
Control Automático
spellingShingle Ingeniería
Diabetes Mellitus Tipo 1
Páncreas Artificial
Control Automático
Fushimi, Emilia
Estrategias de control avanzadas para páncreas artificial
topic_facet Ingeniería
Diabetes Mellitus Tipo 1
Páncreas Artificial
Control Automático
description Artificial Pancreas (AP) systems consist on a subcutaneous insulin pump connected to a continuous glucose monitor (CGM) through a control algorithm that calculates the appropriate insulin dose according to CGM readings. Though great research has been carried in this topic, there are still many limitations that make full closed-loop glycemic control challenging. These limitations include large delays in CGM readings and in the insulin action, intra and inter-patient variability, and the fact that there is no negative action to counteract insulin, among others. Here, several steps towards full closed-loop control are taken. First, hypoglycemia is mitigated using constant and time-varying IOB constraints in hybrid-loop and closed-loop controllers with meal announcement. Then, a switching signal generator is proposed in order to enable automatic switching between closed-loop controllers in a switched control scheme, thus eliminating the need for meal announcement. Lastly, a dual-hormone controller is presented in order to improve the performance achieved by a fully closed-loop, single-hormone control algorithm. Also, in the context of the COVID 19 pandemic, a remote monitoring platform is employed in order to monitor patients in the intensive care unit, thus reducing healthcare profesional exposure. Then, a closed-loop algorithm is tested in the first ambulatory artificial pancreas clinical trials in Argentina.
author2 Garelli, Fabricio
author_facet Garelli, Fabricio
Fushimi, Emilia
format Tesis
Tesis de doctorado
author Fushimi, Emilia
author_sort Fushimi, Emilia
title Estrategias de control avanzadas para páncreas artificial
title_short Estrategias de control avanzadas para páncreas artificial
title_full Estrategias de control avanzadas para páncreas artificial
title_fullStr Estrategias de control avanzadas para páncreas artificial
title_full_unstemmed Estrategias de control avanzadas para páncreas artificial
title_sort estrategias de control avanzadas para páncreas artificial
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/133534
https://doi.org/10.35537/10915/133534
work_keys_str_mv AT fushimiemilia estrategiasdecontrolavanzadasparapancreasartificial
bdutipo_str Repositorios
_version_ 1764820454895255553

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