A rational approach between vitamin d, immunomodulation and the renin-angiotensin system linked to prevention and treatment of severe acute respiratory syndrome by COVID-19

A distinctive feature of COVID-19 is its low mortality rate, where the leading cause of decease is related to the development of severe acute respiratory syndrome (SARS). This syndrome involves an exacerbated inflammatory reaction, frequently known as cytokine storm, mainly in the lungs and concomit...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Martín Giménez, Virna M., Carmona, Maximiliano, Manucha, Walter
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Médicas
Vitamin D
1,25(OH)2D
COVID-19
SARS-CoV-2
Severe acute respiratory syndrome
Síndrome respiratorio agudo severo
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/133483
https://pmr.safisiol.org.ar/uploadsarchivos/vol_14_n_6_2021.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-133483
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Vitamin D
1,25(OH)2D
COVID-19
SARS-CoV-2
Severe acute respiratory syndrome
Síndrome respiratorio agudo severo
spellingShingle Ciencias Médicas
Vitamin D
1,25(OH)2D
COVID-19
SARS-CoV-2
Severe acute respiratory syndrome
Síndrome respiratorio agudo severo
Martín Giménez, Virna M.
Carmona, Maximiliano
Manucha, Walter
A rational approach between vitamin d, immunomodulation and the renin-angiotensin system linked to prevention and treatment of severe acute respiratory syndrome by COVID-19
topic_facet Ciencias Médicas
Vitamin D
1,25(OH)2D
COVID-19
SARS-CoV-2
Severe acute respiratory syndrome
Síndrome respiratorio agudo severo
description A distinctive feature of COVID-19 is its low mortality rate, where the leading cause of decease is related to the development of severe acute respiratory syndrome (SARS). This syndrome involves an exacerbated inflammatory reaction, frequently known as cytokine storm, mainly in the lungs and concomitant over activation of the renin-angiotensin-aldosterone system (RAAS). Consequently, this "explosive cocktail" can lead to death or permanent respiratory sequelae in patients infected with SARSCoV- 2. In this sense, multiple therapeutic strategies have been proposed. Among them, vitamin D stands out as it exerts numerous immunomodulatory effects by acting on various types of immune and epithelial cells, in addition to being able to stimulate the protective arm [(ACE2/Ang- ( 1-7)] and inhibit the damaging arm (ACE/Ang-II) of the RAAS. Therefore, in the present mini-review, some of the main mechanisms underlying these effects mediated by vitamin D and its receptors are analyzed. Knowledge and translational projection of these mechanisms would positively influence the prevention and treatment of SARS. Thus, current evidence on vitamin D and COVID-19 adds arguments to rational therapy regarding reducing or avoiding disease progression and improving prognosis.
format Articulo
Articulo
author Martín Giménez, Virna M.
Carmona, Maximiliano
Manucha, Walter
author_facet Martín Giménez, Virna M.
Carmona, Maximiliano
Manucha, Walter
author_sort Martín Giménez, Virna M.
title A rational approach between vitamin d, immunomodulation and the renin-angiotensin system linked to prevention and treatment of severe acute respiratory syndrome by COVID-19
title_short A rational approach between vitamin d, immunomodulation and the renin-angiotensin system linked to prevention and treatment of severe acute respiratory syndrome by COVID-19
title_full A rational approach between vitamin d, immunomodulation and the renin-angiotensin system linked to prevention and treatment of severe acute respiratory syndrome by COVID-19
title_fullStr A rational approach between vitamin d, immunomodulation and the renin-angiotensin system linked to prevention and treatment of severe acute respiratory syndrome by COVID-19
title_full_unstemmed A rational approach between vitamin d, immunomodulation and the renin-angiotensin system linked to prevention and treatment of severe acute respiratory syndrome by COVID-19
title_sort rational approach between vitamin d, immunomodulation and the renin-angiotensin system linked to prevention and treatment of severe acute respiratory syndrome by covid-19
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/133483
https://pmr.safisiol.org.ar/uploadsarchivos/vol_14_n_6_2021.pdf
work_keys_str_mv AT martingimenezvirnam arationalapproachbetweenvitamindimmunomodulationandthereninangiotensinsystemlinkedtopreventionandtreatmentofsevereacuterespiratorysyndromebycovid19
AT carmonamaximiliano arationalapproachbetweenvitamindimmunomodulationandthereninangiotensinsystemlinkedtopreventionandtreatmentofsevereacuterespiratorysyndromebycovid19
AT manuchawalter arationalapproachbetweenvitamindimmunomodulationandthereninangiotensinsystemlinkedtopreventionandtreatmentofsevereacuterespiratorysyndromebycovid19
AT martingimenezvirnam rationalapproachbetweenvitamindimmunomodulationandthereninangiotensinsystemlinkedtopreventionandtreatmentofsevereacuterespiratorysyndromebycovid19
AT carmonamaximiliano rationalapproachbetweenvitamindimmunomodulationandthereninangiotensinsystemlinkedtopreventionandtreatmentofsevereacuterespiratorysyndromebycovid19
AT manuchawalter rationalapproachbetweenvitamindimmunomodulationandthereninangiotensinsystemlinkedtopreventionandtreatmentofsevereacuterespiratorysyndromebycovid19
bdutipo_str Repositorios
_version_ 1764820454776766464

Ejemplares similares