Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE), the increase in...
Guardado en:
| Autores principales: | , , |
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| Formato: | Libro Capitulo de libro |
| Lenguaje: | Español |
| Publicado: |
Springer
2003
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/133387 |
| Aporte de: |
| Sumario: | An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE), the increase in intracellular Na<sup>+</sup> concentration ([Na<sup>+</sup>]<sub>i</sub>), and the increase in the Ca<sup>2+</sup> transient that underlies the so called slow force response (SFR) to stretch. This autocrine/paracrine mechanism could explain how a change in afterload alters cardiac contractility as was reported by Anrep in 1912. |
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