Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart

An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE), the increase in...

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Autores principales: Cingolani, Horacio Eugenio, Pérez, Néstor Gustavo, Camilión de Hurtado, María Cristina
Formato: Libro Capitulo de libro
Lenguaje:Español
Publicado: Springer 2003
Materias:
Medicina
myocardial stretch
Na+/Ca2+ exchange
angiotensin II
endothelin hypertrophy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/133387
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-133387
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Medicina
myocardial stretch
Na+/Ca2+ exchange
angiotensin II
endothelin hypertrophy
spellingShingle Medicina
myocardial stretch
Na+/Ca2+ exchange
angiotensin II
endothelin hypertrophy
Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Camilión de Hurtado, María Cristina
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart
topic_facet Medicina
myocardial stretch
Na+/Ca2+ exchange
angiotensin II
endothelin hypertrophy
description An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE), the increase in intracellular Na<sup>+</sup> concentration ([Na<sup>+</sup>]<sub>i</sub>), and the increase in the Ca<sup>2+</sup> transient that underlies the so called slow force response (SFR) to stretch. This autocrine/paracrine mechanism could explain how a change in afterload alters cardiac contractility as was reported by Anrep in 1912.
format Libro
Capitulo de libro
author Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Camilión de Hurtado, María Cristina
author_facet Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Camilión de Hurtado, María Cristina
author_sort Cingolani, Horacio Eugenio
title Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart
title_short Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart
title_full Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart
title_fullStr Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart
title_full_unstemmed Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart
title_sort stretch-elicited autocrine/paracrine mechanism in the heart
publisher Springer
publishDate 2003
url http://sedici.unlp.edu.ar/handle/10915/133387
work_keys_str_mv AT cingolanihoracioeugenio stretchelicitedautocrineparacrinemechanismintheheart
AT pereznestorgustavo stretchelicitedautocrineparacrinemechanismintheheart
AT camiliondehurtadomariacristina stretchelicitedautocrineparacrinemechanismintheheart
bdutipo_str Repositorios
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