Intracerebroventricular Delivery of Human Umbilical Cord Mesenchymal Stem Cells as a Promising Therapy for Repairing the Spinal Cord Injury Induced by Kainic Acid

Spinal cord injury (SCI) is a common pathological condition that leads to permanent or temporal loss of motor and autonomic functions. Kainic acid (KA), an agonist of kainate receptors, a type of ionotropic glutamate receptor, is widely used to induce experimental neurodegeneration models of CNS. Me...

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Autores principales: Nishida, Fabián, Zappa Villar, María Florencia, Zanuzzi, Carolina Natalia, Sisti, María Susana, Elea Camiña, Agustina, Reggiani, Paula Cecilia, Portiansky, Enrique Leo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Ciencias Veterinarias
Veterinaria
Experimental SCI
Fourth ventricle
Stem cell therapy
Neurorestauration
Behavioral tests
Astrocytes
Microglía
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/133313
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-133313
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Veterinaria
Experimental SCI
Fourth ventricle
Stem cell therapy
Neurorestauration
Behavioral tests
Astrocytes
Microglía
spellingShingle Ciencias Veterinarias
Veterinaria
Experimental SCI
Fourth ventricle
Stem cell therapy
Neurorestauration
Behavioral tests
Astrocytes
Microglía
Nishida, Fabián
Zappa Villar, María Florencia
Zanuzzi, Carolina Natalia
Sisti, María Susana
Elea Camiña, Agustina
Reggiani, Paula Cecilia
Portiansky, Enrique Leo
Intracerebroventricular Delivery of Human Umbilical Cord Mesenchymal Stem Cells as a Promising Therapy for Repairing the Spinal Cord Injury Induced by Kainic Acid
topic_facet Ciencias Veterinarias
Veterinaria
Experimental SCI
Fourth ventricle
Stem cell therapy
Neurorestauration
Behavioral tests
Astrocytes
Microglía
description Spinal cord injury (SCI) is a common pathological condition that leads to permanent or temporal loss of motor and autonomic functions. Kainic acid (KA), an agonist of kainate receptors, a type of ionotropic glutamate receptor, is widely used to induce experimental neurodegeneration models of CNS. Mesenchymal Stem Cells (MSC) therapy applied at the injured nervous tissue have emerged as a promising therapeutic treatment. Here we used a validated SCI experimental model in which an intraparenchymal injection of KA into the C5 segment of rat spinal cord induced an excitotoxic lesion. Three days later, experimental animals were treated with an intracerebroventricular injection of human umbilical cord (hUC) MSC whereas control group only received saline solution. Sensory and motor skills as well as neuronal and glial reaction of both groups were recorded. Differences in motor behavior, neuronal counting and glial responses were observed between hUC-MSC-treated and untreated rats. According to the obtained results, we suggest that hUC-MSC therapy delivered into the fourth ventricle using the intracerebroventricular via can exert a neuroprotective or neurorestorative effect on KA-injected animals.
format Articulo
Articulo
author Nishida, Fabián
Zappa Villar, María Florencia
Zanuzzi, Carolina Natalia
Sisti, María Susana
Elea Camiña, Agustina
Reggiani, Paula Cecilia
Portiansky, Enrique Leo
author_facet Nishida, Fabián
Zappa Villar, María Florencia
Zanuzzi, Carolina Natalia
Sisti, María Susana
Elea Camiña, Agustina
Reggiani, Paula Cecilia
Portiansky, Enrique Leo
author_sort Nishida, Fabián
title Intracerebroventricular Delivery of Human Umbilical Cord Mesenchymal Stem Cells as a Promising Therapy for Repairing the Spinal Cord Injury Induced by Kainic Acid
title_short Intracerebroventricular Delivery of Human Umbilical Cord Mesenchymal Stem Cells as a Promising Therapy for Repairing the Spinal Cord Injury Induced by Kainic Acid
title_full Intracerebroventricular Delivery of Human Umbilical Cord Mesenchymal Stem Cells as a Promising Therapy for Repairing the Spinal Cord Injury Induced by Kainic Acid
title_fullStr Intracerebroventricular Delivery of Human Umbilical Cord Mesenchymal Stem Cells as a Promising Therapy for Repairing the Spinal Cord Injury Induced by Kainic Acid
title_full_unstemmed Intracerebroventricular Delivery of Human Umbilical Cord Mesenchymal Stem Cells as a Promising Therapy for Repairing the Spinal Cord Injury Induced by Kainic Acid
title_sort intracerebroventricular delivery of human umbilical cord mesenchymal stem cells as a promising therapy for repairing the spinal cord injury induced by kainic acid
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/133313
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