Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture

A recently synthesized vanadyl(IV) complex with aspirin [VO(aspirin)ClH2O]2, has been thoroughly investigated by physicochemical techniques. In order to support the proposed structure, stoichiometry and the coordination sphere of the vanadium center, some studies such as elemental analysis, electron...

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Autores principales: Etcheverry, Susana Beatriz, Williams, Patricia Ana María, Sálice, Viviana C., Barrio, Daniel Alejandro, Ferrer, Evelina Gloria, Cortizo, Ana María
Formato: Articulo
Lenguaje:Español
Publicado: 2002
Materias:
Ciencias Exactas
Química
aspirin
cytotoxicity
osteoblasts
vanadium
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/132747
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-132747
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Exactas
Química
aspirin
cytotoxicity
osteoblasts
vanadium
spellingShingle Ciencias Exactas
Química
aspirin
cytotoxicity
osteoblasts
vanadium
Etcheverry, Susana Beatriz
Williams, Patricia Ana María
Sálice, Viviana C.
Barrio, Daniel Alejandro
Ferrer, Evelina Gloria
Cortizo, Ana María
Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
topic_facet Ciencias Exactas
Química
aspirin
cytotoxicity
osteoblasts
vanadium
description A recently synthesized vanadyl(IV) complex with aspirin [VO(aspirin)ClH2O]2, has been thoroughly investigated by physicochemical techniques. In order to support the proposed structure, stoichiometry and the coordination sphere of the vanadium center, some studies such as elemental analysis, electronic (diffuse reflectance) and vibrational (infrared) spectroscopies, magnetic susceptibility, as well as the thermal behavior, were carried out. The bioactivity of the vanadium complex (VOAspi) was evaluated on two osteoblast-like cell lines in culture, being its cytotoxic effects stronger than the vanadyl cation as assessed by morphological changes and lipid peroxidation. These effects may be partially explained through the induction of the expression of Erks (Extracellular signal-regulated kinases) and the inhibition of the PTPases (Phosphotyrosine phosphatases) present in the cellular extracts.
format Articulo
Articulo
author Etcheverry, Susana Beatriz
Williams, Patricia Ana María
Sálice, Viviana C.
Barrio, Daniel Alejandro
Ferrer, Evelina Gloria
Cortizo, Ana María
author_facet Etcheverry, Susana Beatriz
Williams, Patricia Ana María
Sálice, Viviana C.
Barrio, Daniel Alejandro
Ferrer, Evelina Gloria
Cortizo, Ana María
author_sort Etcheverry, Susana Beatriz
title Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
title_short Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
title_full Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
title_fullStr Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
title_full_unstemmed Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
title_sort biochemical properties and mechanism of action of a vanadyl(iv)-aspirin complex on bone cell lines in culture
publishDate 2002
url http://sedici.unlp.edu.ar/handle/10915/132747
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