In situ Formed Implants, Based on PLGA and Eudragit Blends, for Novel Florfenicol Controlled Release Formulations

Drug controlled release technologies (DCRTs) represent an opportunity for designing new therapies. Main objectives are dose number optimization and secondary effects reduction to improve the level of patient/client acceptance. The present work studies DCRTs based in blended polymeric implants for si...

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Autores principales: Karp, Federico, Turino, Ludmila Noelia, Helbling, Ignacio Marcelo, Islan, Germán Abel, Luna, Julio Alberto, Estenoz, Diana Alejandra
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Química
Farmacia
Drug delivery systems
Polymers
Antibiotics
Florfenicol
Controlled release
Biocompatible solvent
Biocompatible polymers
PLGA
Eudragit polymers
Autocatalytic effect
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/132559
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-132559
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Farmacia
Drug delivery systems
Polymers
Antibiotics
Florfenicol
Controlled release
Biocompatible solvent
Biocompatible polymers
PLGA
Eudragit polymers
Autocatalytic effect
spellingShingle Química
Farmacia
Drug delivery systems
Polymers
Antibiotics
Florfenicol
Controlled release
Biocompatible solvent
Biocompatible polymers
PLGA
Eudragit polymers
Autocatalytic effect
Karp, Federico
Turino, Ludmila Noelia
Helbling, Ignacio Marcelo
Islan, Germán Abel
Luna, Julio Alberto
Estenoz, Diana Alejandra
In situ Formed Implants, Based on PLGA and Eudragit Blends, for Novel Florfenicol Controlled Release Formulations
topic_facet Química
Farmacia
Drug delivery systems
Polymers
Antibiotics
Florfenicol
Controlled release
Biocompatible solvent
Biocompatible polymers
PLGA
Eudragit polymers
Autocatalytic effect
description Drug controlled release technologies (DCRTs) represent an opportunity for designing new therapies. Main objectives are dose number optimization and secondary effects reduction to improve the level of patient/client acceptance. The present work studies DCRTs based in blended polymeric implants for single dose and long-term therapies of florfenicol (FF), a broad spectrum antibiotic. Polymers used were PLGA and Eudragit E100/S100 types. Eudragit/PLGA and FF/PLGA ratios were the main studied factors in terms of encapsulation efficiencies (EEs) and drug release profiles. In addition, morphological and physicochemical characterization were carried out. EEs were of 50-100% depending on formulation composition, and the FF releasing rate was increased or diminished when E100 or S100 were added, respectively. PLGA hydrolytic cleavage products possibly affect Eudragit solubility and matrix stability. Different mathematical models were used for better understanding and simulating release processes. Implants maintained the antimicrobial activity against Pseudomonas aeruginosa up to 12 days on agar plates. The developed DCRTs represents a suitable alternative for florfenicol long-term therapies.
format Articulo
Articulo
author Karp, Federico
Turino, Ludmila Noelia
Helbling, Ignacio Marcelo
Islan, Germán Abel
Luna, Julio Alberto
Estenoz, Diana Alejandra
author_facet Karp, Federico
Turino, Ludmila Noelia
Helbling, Ignacio Marcelo
Islan, Germán Abel
Luna, Julio Alberto
Estenoz, Diana Alejandra
author_sort Karp, Federico
title In situ Formed Implants, Based on PLGA and Eudragit Blends, for Novel Florfenicol Controlled Release Formulations
title_short In situ Formed Implants, Based on PLGA and Eudragit Blends, for Novel Florfenicol Controlled Release Formulations
title_full In situ Formed Implants, Based on PLGA and Eudragit Blends, for Novel Florfenicol Controlled Release Formulations
title_fullStr In situ Formed Implants, Based on PLGA and Eudragit Blends, for Novel Florfenicol Controlled Release Formulations
title_full_unstemmed In situ Formed Implants, Based on PLGA and Eudragit Blends, for Novel Florfenicol Controlled Release Formulations
title_sort in situ formed implants, based on plga and eudragit blends, for novel florfenicol controlled release formulations
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/132559
work_keys_str_mv AT karpfederico insituformedimplantsbasedonplgaandeudragitblendsfornovelflorfenicolcontrolledreleaseformulations
AT turinoludmilanoelia insituformedimplantsbasedonplgaandeudragitblendsfornovelflorfenicolcontrolledreleaseformulations
AT helblingignaciomarcelo insituformedimplantsbasedonplgaandeudragitblendsfornovelflorfenicolcontrolledreleaseformulations
AT islangermanabel insituformedimplantsbasedonplgaandeudragitblendsfornovelflorfenicolcontrolledreleaseformulations
AT lunajulioalberto insituformedimplantsbasedonplgaandeudragitblendsfornovelflorfenicolcontrolledreleaseformulations
AT estenozdianaalejandra insituformedimplantsbasedonplgaandeudragitblendsfornovelflorfenicolcontrolledreleaseformulations
bdutipo_str Repositorios
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