Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats

Fatty acid desaturase activities were determined in liver microsomes from calcium-deficient rats and compared to calcium-sufficient ones. The calcium-deprived diet (0.5 g/kg) administered for 60 d caused a 30% inhibition in the Δ5 desaturase activity and a 45–55% decrease in Δ6 and Δ9, respectively,...

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Detalles Bibliográficos
Autores principales: Marra, Carlos Alberto, Tacconi de Alaniz, María Josefa
Formato: Articulo
Lenguaje:Inglés
Publicado: 2000
Materias:
Bioquímica
Calcium
Unsaturated fatty acid
Phospholipase A2
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/132519
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-132519
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Calcium
Unsaturated fatty acid
Phospholipase A2
spellingShingle Bioquímica
Calcium
Unsaturated fatty acid
Phospholipase A2
Marra, Carlos Alberto
Tacconi de Alaniz, María Josefa
Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
topic_facet Bioquímica
Calcium
Unsaturated fatty acid
Phospholipase A2
description Fatty acid desaturase activities were determined in liver microsomes from calcium-deficient rats and compared to calcium-sufficient ones. The calcium-deprived diet (0.5 g/kg) administered for 60 d caused a 30% inhibition in the Δ5 desaturase activity and a 45–55% decrease in Δ6 and Δ9, respectively, facts that cannot be attributed to a reduction in food intake. In vitro addition of calcium, ethyleneglycol-bis(β-aminoethyl ether)N,N-tetraacetic acid, and/or cytosol fractions from control or calcium-deficient rats to microsomes from both groups of animals indicates that the reduced desaturase capacities would be the consequence of an indirect effect of calcium deprivation. The present work shows that the reduced unsaturated fatty acid biosynthesis might be the result of modifications in the physicochemical properties of microsomal membranes. Such changes could also be derived from the inhibition of phospholipase A2 activity induced by calcium deficiency.
format Articulo
Articulo
author Marra, Carlos Alberto
Tacconi de Alaniz, María Josefa
author_facet Marra, Carlos Alberto
Tacconi de Alaniz, María Josefa
author_sort Marra, Carlos Alberto
title Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
title_short Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
title_full Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
title_fullStr Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
title_full_unstemmed Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
title_sort calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
publishDate 2000
url http://sedici.unlp.edu.ar/handle/10915/132519
work_keys_str_mv AT marracarlosalberto calciumdeficiencymodifiespolyunsaturatedfattyacidmetabolismingrowingrats
AT tacconidealanizmariajosefa calciumdeficiencymodifiespolyunsaturatedfattyacidmetabolismingrowingrats
bdutipo_str Repositorios
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