Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia

Comparative genomic hybridization (CGH) was used to detect changes in DNA copy number in 25 cases of refractory acute myeloid leukemia (AML). CGH detected changes in DNA copy number in nine AML (36%). Losses (82%) were more frequent than gains (18%). No high-level amplifications were detected in any...

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Autores principales: El-Rifai, Wael, Elonen, Erkki, Larramendy, Marcelo Luis, Ruutu, Tapani, Knuutila, Sakari
Formato: Articulo
Lenguaje:Inglés
Publicado: 1997
Materias:
Biología
Ciencias Médicas
CGH
refractory AML
5q; 7q
12p
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/132500
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-132500
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Ciencias Médicas
CGH
refractory AML
5q; 7q
12p
spellingShingle Biología
Ciencias Médicas
CGH
refractory AML
5q; 7q
12p
El-Rifai, Wael
Elonen, Erkki
Larramendy, Marcelo Luis
Ruutu, Tapani
Knuutila, Sakari
Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
topic_facet Biología
Ciencias Médicas
CGH
refractory AML
5q; 7q
12p
description Comparative genomic hybridization (CGH) was used to detect changes in DNA copy number in 25 cases of refractory acute myeloid leukemia (AML). CGH detected changes in DNA copy number in nine AML (36%). Losses (82%) were more frequent than gains (18%). No high-level amplifications were detected in any of the cases. Losses involved minimal overlapping regions at 5q14q32, 7q31.2q32 and 12p12. The most frequent gain was detected at 8q. CGH gave normal results in all cases with a normal karyotype or a translocation as the sole aberration. The absence of high-level DNA copy gains suggests that, in contrast to other malignancies, gene amplification is not an important mechanism for drug resistance in AML. In addition to 5q and 7q, known to be associated with disease refractoriness, 12p may be another region related to poor prognosis.
format Articulo
Articulo
author El-Rifai, Wael
Elonen, Erkki
Larramendy, Marcelo Luis
Ruutu, Tapani
Knuutila, Sakari
author_facet El-Rifai, Wael
Elonen, Erkki
Larramendy, Marcelo Luis
Ruutu, Tapani
Knuutila, Sakari
author_sort El-Rifai, Wael
title Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
title_short Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
title_full Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
title_fullStr Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
title_full_unstemmed Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia
title_sort chromosomal breakpoints and changes in dna copy number in refractory acute myeloid leukemia
publishDate 1997
url http://sedici.unlp.edu.ar/handle/10915/132500
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