Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype

The hypothalamic damage induced by neonatal treatment with monosodium l-glutamate (MSG) induces several metabolic abnormalities, resulting in a rat hyperleptinemic–hyperadipose phenotype. This study was conducted to explore the impact of the neonatal MSG treatment, in the adult (120 days old) female...

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Detalles Bibliográficos
Autores principales: Perelló, Mario Carlos, Console-Avegliano, Gloria Miriam, Gaillard, Rolf C., Spinedi, Eduardo Julio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Ciencias Médicas
Hypothalamic obesity
Hypophagia
Mineralocorticoid
Omental adiposity
Glucocorticoid
Leptin
Insulin
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/132244
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-132244
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Hypothalamic obesity
Hypophagia
Mineralocorticoid
Omental adiposity
Glucocorticoid
Leptin
Insulin
spellingShingle Ciencias Médicas
Hypothalamic obesity
Hypophagia
Mineralocorticoid
Omental adiposity
Glucocorticoid
Leptin
Insulin
Perelló, Mario Carlos
Console-Avegliano, Gloria Miriam
Gaillard, Rolf C.
Spinedi, Eduardo Julio
Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
topic_facet Ciencias Médicas
Hypothalamic obesity
Hypophagia
Mineralocorticoid
Omental adiposity
Glucocorticoid
Leptin
Insulin
description The hypothalamic damage induced by neonatal treatment with monosodium l-glutamate (MSG) induces several metabolic abnormalities, resulting in a rat hyperleptinemic–hyperadipose phenotype. This study was conducted to explore the impact of the neonatal MSG treatment, in the adult (120 days old) female rat on: (a) the in vivo and in vitro mineralocorticoid responses to ACTH and angiotensin II (AII); (b) the effect of leptin on ACTH- and AII-stimulated mineralocorticoid secretions by isolated corticoadrenal cells; and (c) abdominal adiposity characteristics. Our data indicate that, compared with age-matched controls, MSG rats displayed: (1) enhanced and reduced mineralocorticoid responses to ACTH and AII treatments, respectively, effects observed in both in vivo and in vitro conditions; (2) adrenal refractoriness to the inhibitory effect of exogenous leptin on ACTH-stimulated aldosterone output by isolated adrenocortical cells; and (3) distorted omental adiposity morphology and function. This study supports that the adult hyperleptinemic MSG female rat is characterized by enhanced ACTH-driven mineralocorticoid function, impaired adrenal leptin sensitivity, and disrupted abdominal adiposity function. MSG rats could counteract undesirable effects of glucocorticoid excess, by developing a reduced AII-driven mineralocorticoid function. Thus, chronic hyperleptinemia could play a protective role against ACTH-mediated allostatic loads in the adrenal leptin resistant, MSG female rat phenotype.
format Articulo
Articulo
author Perelló, Mario Carlos
Console-Avegliano, Gloria Miriam
Gaillard, Rolf C.
Spinedi, Eduardo Julio
author_facet Perelló, Mario Carlos
Console-Avegliano, Gloria Miriam
Gaillard, Rolf C.
Spinedi, Eduardo Julio
author_sort Perelló, Mario Carlos
title Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
title_short Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
title_full Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
title_fullStr Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
title_full_unstemmed Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
title_sort analysis of angiotensin ii- and acth-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/132244
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