Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex

A new complex of the oxovanadium(IV) cation with the flavolignan silibinin has been synthesized and characterized. Vanadium compounds show interesting biological and pharmacological properties and some of them display antitumoral actions. Flavonoids are part of a larger group of antioxidant compound...

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Detalles Bibliográficos
Autores principales: Naso, Luciana, Ferrer, Evelina Gloria, Butenko, Nataliya, Cavaco, Isabel, Lezama, Luis, Rojo, Teófilo, Etcheverry, Susana Beatriz, Williams, Patricia Ana María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Química
Oxovanadium(IV)
Silibinin
Osteoblasts
Antioxidant
Antitumoral
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131709
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131709
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Oxovanadium(IV)
Silibinin
Osteoblasts
Antioxidant
Antitumoral
spellingShingle Química
Oxovanadium(IV)
Silibinin
Osteoblasts
Antioxidant
Antitumoral
Naso, Luciana
Ferrer, Evelina Gloria
Butenko, Nataliya
Cavaco, Isabel
Lezama, Luis
Rojo, Teófilo
Etcheverry, Susana Beatriz
Williams, Patricia Ana María
Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex
topic_facet Química
Oxovanadium(IV)
Silibinin
Osteoblasts
Antioxidant
Antitumoral
description A new complex of the oxovanadium(IV) cation with the flavolignan silibinin has been synthesized and characterized. Vanadium compounds show interesting biological and pharmacological properties and some of them display antitumoral actions. Flavonoids are part of a larger group of antioxidant compounds called polyphenols which may inhibit the proliferation and growth of cancer cells. The antioxidant and antitumoral effects of silibinin and its oxovanadium(IV) complex were investigated. Silibinin acted as a very strong antioxidant and its complexation with oxovanadium(IV) improved this behavior. Besides, the generation of reactive oxygen species (ROS) by this compound was favored in tumoral (UMR106) cells and correlated with the deleterious behavior in the proliferation of this cell line. Conversely, silibinin did not exert any effect on the proliferation of normal osteoblasts (MC3T3E1). The cytotoxic action and ROS generation of the oxovanadium(IV) complex was more effective in tumoral cells. This behavior was not consistent with cleaving DNA of plasmid DNA pA1 because no significant cleaving activity was observed in both cases. These results suggest that the main deleterious mechanisms may take place through cytotoxic effects more than genotoxic actions. A comparison with our own findings on the behavior of other flavonoids and their vanadyl(IV) complex has also been performed.
format Articulo
Articulo
author Naso, Luciana
Ferrer, Evelina Gloria
Butenko, Nataliya
Cavaco, Isabel
Lezama, Luis
Rojo, Teófilo
Etcheverry, Susana Beatriz
Williams, Patricia Ana María
author_facet Naso, Luciana
Ferrer, Evelina Gloria
Butenko, Nataliya
Cavaco, Isabel
Lezama, Luis
Rojo, Teófilo
Etcheverry, Susana Beatriz
Williams, Patricia Ana María
author_sort Naso, Luciana
title Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex
title_short Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex
title_full Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex
title_fullStr Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex
title_full_unstemmed Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex
title_sort antioxidant, dna cleavage, and cellular effects of silibinin and a new oxovanadium(iv)/silibinin complex
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/131709
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