Effects of an intraparenchymal injection of lidocaine in the rat cervical spinal cord

Lidocaine effects in the spinal cord have been extensively investigated over the years. Although the intrathecal route is usually used to treat insults occurring in the spinal cord, the local delivery drug via intraparenchymal infusions has gained increasing favor for the treatment of some neurodege...

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Autores principales: Sisti, María Susana, Zanuzzi, Carolina Natalia, Nishida, Fabián, Cantet, Rodolfo Juan Carlos, Portiansky, Enrique Leo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Veterinarias
Spinal cord injury
Local anesthetic
Drug delivery
Toxic effect
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131399
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131399
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Spinal cord injury
Local anesthetic
Drug delivery
Toxic effect
spellingShingle Ciencias Veterinarias
Spinal cord injury
Local anesthetic
Drug delivery
Toxic effect
Sisti, María Susana
Zanuzzi, Carolina Natalia
Nishida, Fabián
Cantet, Rodolfo Juan Carlos
Portiansky, Enrique Leo
Effects of an intraparenchymal injection of lidocaine in the rat cervical spinal cord
topic_facet Ciencias Veterinarias
Spinal cord injury
Local anesthetic
Drug delivery
Toxic effect
description Lidocaine effects in the spinal cord have been extensively investigated over the years. Although the intrathecal route is usually used to treat insults occurring in the spinal cord, the local delivery drug via intraparenchymal infusions has gained increasing favor for the treatment of some neurodegenerative disorders. The aim of the present study was to evaluate the behavioral and tissue effects of the intraparenchymal injection of different concentrations of lidocaine into the rat cervical spinal cord. Young male Sprague-Dawley rats were intraparenchymally injected with 0.5%, 1% or 2% lidocaine at the C5 segment of the spinal cord. Other rats were injected with saline solution (sham group). Hot plate test was determined at 0, 1, 2, 3, 7 and 14 post-injection (pi) days. Rats of each experimental group were euthanized either at 1, 2, 3, 7 or 14 pi days. Intact animals were used as controls. Sections of the C5 segment were used for histological, immunohistochemical or immunofluorescence analysis. Injection of 0.5% lidocaine did not affect neuronal counting, did not evoke an inflammatory reaction, nor induce astrocyte activation. Therefore, a concentration of 0.5% lidocaine is suggested to promote anti-inflammatory effects after injury.
format Articulo
Articulo
author Sisti, María Susana
Zanuzzi, Carolina Natalia
Nishida, Fabián
Cantet, Rodolfo Juan Carlos
Portiansky, Enrique Leo
author_facet Sisti, María Susana
Zanuzzi, Carolina Natalia
Nishida, Fabián
Cantet, Rodolfo Juan Carlos
Portiansky, Enrique Leo
author_sort Sisti, María Susana
title Effects of an intraparenchymal injection of lidocaine in the rat cervical spinal cord
title_short Effects of an intraparenchymal injection of lidocaine in the rat cervical spinal cord
title_full Effects of an intraparenchymal injection of lidocaine in the rat cervical spinal cord
title_fullStr Effects of an intraparenchymal injection of lidocaine in the rat cervical spinal cord
title_full_unstemmed Effects of an intraparenchymal injection of lidocaine in the rat cervical spinal cord
title_sort effects of an intraparenchymal injection of lidocaine in the rat cervical spinal cord
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/131399
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