Autophagy, physiology and cell pathology

Autophagy plays an important role in human pathologies, such as miopathies and neurodegenerative diseases. Moreover, metabolic disease processes such as diabetes and pancreatitis, as well as tumor cells and cancer chemotherapy, activate autophagy. Furthermore, a selective type of autophagy of pancre...

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Detalles Bibliográficos
Autor principal: Vaccaro, María Inés
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Médicas
Autophagy
VMP1
Zymophagy
mTOR
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131291
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131291
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Autophagy
VMP1
Zymophagy
mTOR
spellingShingle Ciencias Médicas
Autophagy
VMP1
Zymophagy
mTOR
Vaccaro, María Inés
Autophagy, physiology and cell pathology
topic_facet Ciencias Médicas
Autophagy
VMP1
Zymophagy
mTOR
description Autophagy plays an important role in human pathologies, such as miopathies and neurodegenerative diseases. Moreover, metabolic disease processes such as diabetes and pancreatitis, as well as tumor cells and cancer chemotherapy, activate autophagy. Furthermore, a selective type of autophagy of pancreatic zymogen granules has been discovered and characterized as a protective cellular process triggered by acute pancreatitis. In this review we describe the physiological bases and molecular mechanisms in the autophagic process and the possible role of autophagy in human disease. Understanding the events and molecular mechanisms of this complex cellular process will help in the design of new strategies for more effective diagnosis and treatment.
format Articulo
Articulo
author Vaccaro, María Inés
author_facet Vaccaro, María Inés
author_sort Vaccaro, María Inés
title Autophagy, physiology and cell pathology
title_short Autophagy, physiology and cell pathology
title_full Autophagy, physiology and cell pathology
title_fullStr Autophagy, physiology and cell pathology
title_full_unstemmed Autophagy, physiology and cell pathology
title_sort autophagy, physiology and cell pathology
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/131291
work_keys_str_mv AT vaccaromariaines autophagyphysiologyandcellpathology
bdutipo_str Repositorios
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