Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin

Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. After its discovery and initial characterization in the ‘70s, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, a growing core of information, t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pardo, Joaquín, Schwerdt, José Ignacio, Reggiani, Paula Cecilia, Zappa, María Eugenia, Pereyra, Andrea Soledad, Brown, Oscar Alfredo, Goya, Juan Francisco
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Ciencias Médicas thymulin neuroendocrine control hypophysiotropic activity artificial gene gene therapy anti-inflammatory ovarian dysgenesis
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/131279 https://pmr.safisiol.org.ar/uploadsarchivos/vol_6__1__physiology_w3.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-131279
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas thymulin neuroendocrine control hypophysiotropic activity artificial gene gene therapy anti-inflammatory ovarian dysgenesis
spellingShingle	Ciencias Médicas thymulin neuroendocrine control hypophysiotropic activity artificial gene gene therapy anti-inflammatory ovarian dysgenesis Pardo, Joaquín Schwerdt, José Ignacio Reggiani, Paula Cecilia Zappa, María Eugenia Pereyra, Andrea Soledad Brown, Oscar Alfredo Goya, Juan Francisco Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
topic_facet	Ciencias Médicas thymulin neuroendocrine control hypophysiotropic activity artificial gene gene therapy anti-inflammatory ovarian dysgenesis
description	Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. After its discovery and initial characterization in the ‘70s, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, a growing core of information, to be reviewed here, points to thymulin as a hypophysiotropic peptide. Additionally, the substantial body of evidence pointing to thymulin and some synthetic analogs as anti-inflammatory and analgesic molecules in the brain and other organs will be also reviewed. In recent years, a synthetic DNA sequence coding for a biologically active analog of thymulin, metFTS, was constructed and cloned in different adenoviral vectors. A number of recent studies suggest that thymulin gene therapy may be a suitable therapeutic strategy to prevent some of the endocrine and reproductive alterations that typically appear in congenitally athymic (nude) mice, used as a suitable model of neuroendocrine and reproductive aging. Summing up, the present article briefly reviews the literature on the physiology of the thymulin-neuroendocrine axis and the anti-inflammatory properties of the molecule and its analogs. The availability of novel biotechnological tools should boost basic studies on the molecular biology of thymulin and should also allow an assessment of the potential of gene therapy to restore circulating thymulin levels in thymodeficient animal models and eventually, in humans.
format	Articulo Articulo
author	Pardo, Joaquín Schwerdt, José Ignacio Reggiani, Paula Cecilia Zappa, María Eugenia Pereyra, Andrea Soledad Brown, Oscar Alfredo Goya, Juan Francisco
author_facet	Pardo, Joaquín Schwerdt, José Ignacio Reggiani, Paula Cecilia Zappa, María Eugenia Pereyra, Andrea Soledad Brown, Oscar Alfredo Goya, Juan Francisco
author_sort	Pardo, Joaquín
title	Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
title_short	Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
title_full	Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
title_fullStr	Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
title_full_unstemmed	Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
title_sort	physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/131279 https://pmr.safisiol.org.ar/uploadsarchivos/vol_6__1__physiology_w3.pdf
work_keys_str_mv	AT pardojoaquin physiologymolecularbiologyandtherapeuticpotentialofthethymicpeptidethymulin AT schwerdtjoseignacio physiologymolecularbiologyandtherapeuticpotentialofthethymicpeptidethymulin AT reggianipaulacecilia physiologymolecularbiologyandtherapeuticpotentialofthethymicpeptidethymulin AT zappamariaeugenia physiologymolecularbiologyandtherapeuticpotentialofthethymicpeptidethymulin AT pereyraandreasoledad physiologymolecularbiologyandtherapeuticpotentialofthethymicpeptidethymulin AT brownoscaralfredo physiologymolecularbiologyandtherapeuticpotentialofthethymicpeptidethymulin AT goyajuanfrancisco physiologymolecularbiologyandtherapeuticpotentialofthethymicpeptidethymulin
bdutipo_str	Repositorios
_version_	1764820453584535552

Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin

Ejemplares similares