Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring

Malnutrition induces profound deleterious effects on several metabolic and neuroendocrine functions. In the present study, we examined the impact of maternal food restriction, during gestation and lactation, on the metabolic-neuroendocrine function of their male offspring at 21 and 60 d of age. Well...

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Autores principales: Chisari, Andrea Nancy, Giovambattista, Andrés, Perelló, Mario Carlos, Spinedi, Eduardo Julio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2001
Materias:
Ciencias Exactas
Biología
adrenocorticotropic hormone
glucocorticoid
carbohydrate
leptin
foodrestriction
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131261
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131261
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Biología
adrenocorticotropic hormone
glucocorticoid
carbohydrate
leptin
foodrestriction
spellingShingle Ciencias Exactas
Biología
adrenocorticotropic hormone
glucocorticoid
carbohydrate
leptin
foodrestriction
Chisari, Andrea Nancy
Giovambattista, Andrés
Perelló, Mario Carlos
Spinedi, Eduardo Julio
Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
topic_facet Ciencias Exactas
Biología
adrenocorticotropic hormone
glucocorticoid
carbohydrate
leptin
foodrestriction
description Malnutrition induces profound deleterious effects on several metabolic and neuroendocrine functions. In the present study, we examined the impact of maternal food restriction, during gestation and lactation, on the metabolic-neuroendocrine function of their male offspring at 21 and 60 d of age. Well-nourished (WN) and undernourished (UN) pregnant rats were used, during gestation and lactation, until pups were weaned. Twenty-one-day-old WN and UN male pups were studied in basal and postinsulin conditions. Additional groups of weaned (WN and UN) male rats were fed either ad libitum (WN-WN and UN-WN) or in a restricted fashion (WN-UN and UN-UN) until experimentation at age 60 d. Body weights of mothers and their male offspring were monitored. Basal and post-insulin plasma concentrations of several metabolic fuels were evaluated. Our results indicate that 21-d-old UN male rats exhibited (vs their WN counterparts), decreased body weights, similar basal and postinsulin glycemia, similar basal plasma adrenocorticotropic hormone (ACTH) and corticosterone levels but diminished ACTH response to insulin treatment, and basal hypoleptinemia and significant insulin-induced leptin release. Finally, at 60 d of age, long-term UN (WN-UN and UN-UN) rats showed lower plasma (basal and postinsulin) glucose, and basal triglyceride levels than their counterparts (WN-WN and UN-WN). Sixty-day-old rats submitted to either food restriction protocol also showed a reduced hypothalamo-pituitary-adrenalaxis response to insulin-induced hypoglycemia and basal hypoleptinemia, in spite of restoration of normal body weights. These results further indicate a clear metabolic-neuroendocrine dysfunction in male pups of UN mothers, with the abnormality partially present at weaning and deteriorated by adulthood, even after the recovery of normal body weight. Our study strongly supports the importance of the irreversibility of a deleterious allostatic state resulting from fetal and early postnatal undernutrition.
format Articulo
Articulo
author Chisari, Andrea Nancy
Giovambattista, Andrés
Perelló, Mario Carlos
Spinedi, Eduardo Julio
author_facet Chisari, Andrea Nancy
Giovambattista, Andrés
Perelló, Mario Carlos
Spinedi, Eduardo Julio
author_sort Chisari, Andrea Nancy
title Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
title_short Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
title_full Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
title_fullStr Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
title_full_unstemmed Impact of Maternal Undernutrition on Hypothalamo-Pituitary-Adrenal Axis and Adipocyte Functions in Male Rat Offspring
title_sort impact of maternal undernutrition on hypothalamo-pituitary-adrenal axis and adipocyte functions in male rat offspring
publishDate 2001
url http://sedici.unlp.edu.ar/handle/10915/131261
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