Role of autocrine/paracrine mechanisms in response to myocardial strain

Myocardial strain triggers an autocrine/paracrine mechanism known to participate in myocardial hypertrophy development. After the onset of stretch, there is a rapid augmentation in developed tension due to an increase in myofilament calcium sensitivity (the Frank Starling mechanism) followed by a gr...

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Autores principales: Cingolani, Horacio Eugenio, Ennis, Irene Lucía, Aiello, Ernesto Alejandro, Pérez, Néstor Gustavo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Medicina
Stretch
Sodium–hydrogen exchange
Hypertrophy
Angiotensin
Endothelin
Epidermal growth factor
Oxidative stress
Contractility
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131242
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131242
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Stretch
Sodium–hydrogen exchange
Hypertrophy
Angiotensin
Endothelin
Epidermal growth factor
Oxidative stress
Contractility
spellingShingle Medicina
Stretch
Sodium–hydrogen exchange
Hypertrophy
Angiotensin
Endothelin
Epidermal growth factor
Oxidative stress
Contractility
Cingolani, Horacio Eugenio
Ennis, Irene Lucía
Aiello, Ernesto Alejandro
Pérez, Néstor Gustavo
Role of autocrine/paracrine mechanisms in response to myocardial strain
topic_facet Medicina
Stretch
Sodium–hydrogen exchange
Hypertrophy
Angiotensin
Endothelin
Epidermal growth factor
Oxidative stress
Contractility
description Myocardial strain triggers an autocrine/paracrine mechanism known to participate in myocardial hypertrophy development. After the onset of stretch, there is a rapid augmentation in developed tension due to an increase in myofilament calcium sensitivity (the Frank Starling mechanism) followed by a gradual increase in tension over the next 10-15 min. This second phase is called the slow force response (SFR) to stretch and is known to be the result of an increase in calcium transient amplitude. In the present review, we will discuss what is known thus far about the SFR, which is the in vitro equivalent of the Anrep effect and the mechanical counterpart of the autocrine/ paracrine mechanism elicited by myocardial stretch. The chain of events triggered by myocardial stretch comprises: (1) release of angiotensin II, (2) release/formation of endothelin, (3) NADPH oxidase activation and transactivation of the EGFR, (4) mitochondrial reactive oxygen species production, (5) activation of redox-sensitive kinases, (6) NHE-1 hyperactivity, (7) increase in intracellular Na⁺ concentration, and (8) increase in Ca²⁺ transient amplitude through the Na⁺/Ca²⁺ exchanger. The evidence for each step of the intracellular signaling pathway leading to the development of SFR and their relationship with the mechanisms proposed for cardiac hypertrophy development will be analyzed.
format Articulo
Articulo
author Cingolani, Horacio Eugenio
Ennis, Irene Lucía
Aiello, Ernesto Alejandro
Pérez, Néstor Gustavo
author_facet Cingolani, Horacio Eugenio
Ennis, Irene Lucía
Aiello, Ernesto Alejandro
Pérez, Néstor Gustavo
author_sort Cingolani, Horacio Eugenio
title Role of autocrine/paracrine mechanisms in response to myocardial strain
title_short Role of autocrine/paracrine mechanisms in response to myocardial strain
title_full Role of autocrine/paracrine mechanisms in response to myocardial strain
title_fullStr Role of autocrine/paracrine mechanisms in response to myocardial strain
title_full_unstemmed Role of autocrine/paracrine mechanisms in response to myocardial strain
title_sort role of autocrine/paracrine mechanisms in response to myocardial strain
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/131242
work_keys_str_mv AT cingolanihoracioeugenio roleofautocrineparacrinemechanismsinresponsetomyocardialstrain
AT ennisirenelucia roleofautocrineparacrinemechanismsinresponsetomyocardialstrain
AT aielloernestoalejandro roleofautocrineparacrinemechanismsinresponsetomyocardialstrain
AT pereznestorgustavo roleofautocrineparacrinemechanismsinresponsetomyocardialstrain
bdutipo_str Repositorios
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