Monitoring human genotoxicity risk associated to urban and industrial Buenos Aires air pollution exposure

The quality of life in large megacities is directly affected by its air quality. In urban environments, suspended particles from anthropogenic origin is one of the main air contaminants identified as highly genotoxic, mutagenic, or carcinogenic. Atmospheric monitoring is therefore imperative, and bi...

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Autores principales: Gutiérrez, María de los Ángeles, Palmieri, Mónica A., Giuliani, Daniela Silvana, Colman Lerner, Jorge Esteban, Maglione, Guillermo Alberto, Andrinolo, Darío, Tasat, Deborah Ruth
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Biología
Química
Air pollution
Urban environment
Industrial environment
Genotoxicity
Micronucleus
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131213
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131213
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Química
Air pollution
Urban environment
Industrial environment
Genotoxicity
Micronucleus
spellingShingle Biología
Química
Air pollution
Urban environment
Industrial environment
Genotoxicity
Micronucleus
Gutiérrez, María de los Ángeles
Palmieri, Mónica A.
Giuliani, Daniela Silvana
Colman Lerner, Jorge Esteban
Maglione, Guillermo Alberto
Andrinolo, Darío
Tasat, Deborah Ruth
Monitoring human genotoxicity risk associated to urban and industrial Buenos Aires air pollution exposure
topic_facet Biología
Química
Air pollution
Urban environment
Industrial environment
Genotoxicity
Micronucleus
description The quality of life in large megacities is directly affected by its air quality. In urban environments, suspended particles from anthropogenic origin is one of the main air contaminants identified as highly genotoxic, mutagenic, or carcinogenic. Atmospheric monitoring is therefore imperative, and bioassays to detect the effects of genotoxic agents give usually excellent results. Analysis of micronucleus (MN) in exfoliated oral mucosa cells is a sensitive non-invasive method for monitoring genetic damage in human populations. The first aim of this study was to analyze and characterize levels of volatile organic compounds (VOCs), particulate matter (PM), and polycyclic aromatic hydrocarbons (PAHs) in two areas from Buenos Aires: La Plata city, an urban (U) area and Ensenada, an industrial (I) area. Secondly, we evaluated the possible health risk of its inhabitants through a simple genotoxic assay on exfoliated oral mucosa cells. Whole blood cell count and nuclear abnormalities frequencies were evaluated in the exfoliated oral mucosa cells from urban and industrial inhabitants. Smoking habit represented a significant factor increasing MN percentage while, age did not increase the production of any of the nuclear aberrations assayed (micronuclei, binucleated, karyorrhexis) when the inhabitants from the urban and the industrial areas were compared. In addition, changes in MN and binucleated cell percentages in males and females were found to be area-dependent. We suggest that regardless PM concentration, PM-specific characteristics (size, shape, chemical elements, etc.) and VOCs levels could be responsible for the different harmful genotoxic effects seen in the two areas. Although this is a preliminary study, our results allowed to recognize that individuals living in both the urban and the industrial areas could be considered susceptible groups and should periodically undergo biological monitoring and appropriate care.
format Articulo
Articulo
author Gutiérrez, María de los Ángeles
Palmieri, Mónica A.
Giuliani, Daniela Silvana
Colman Lerner, Jorge Esteban
Maglione, Guillermo Alberto
Andrinolo, Darío
Tasat, Deborah Ruth
author_facet Gutiérrez, María de los Ángeles
Palmieri, Mónica A.
Giuliani, Daniela Silvana
Colman Lerner, Jorge Esteban
Maglione, Guillermo Alberto
Andrinolo, Darío
Tasat, Deborah Ruth
author_sort Gutiérrez, María de los Ángeles
title Monitoring human genotoxicity risk associated to urban and industrial Buenos Aires air pollution exposure
title_short Monitoring human genotoxicity risk associated to urban and industrial Buenos Aires air pollution exposure
title_full Monitoring human genotoxicity risk associated to urban and industrial Buenos Aires air pollution exposure
title_fullStr Monitoring human genotoxicity risk associated to urban and industrial Buenos Aires air pollution exposure
title_full_unstemmed Monitoring human genotoxicity risk associated to urban and industrial Buenos Aires air pollution exposure
title_sort monitoring human genotoxicity risk associated to urban and industrial buenos aires air pollution exposure
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/131213
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