Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study—Antitumor Action on Human Bone and Colorectal Cancer Cell Lines

The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study....

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Detalles Bibliográficos
Autores principales: León, Ignacio Esteban, Ruiz, María Carolina, Franca, Carlos Alberto, Parajón Costa, Beatriz Susana, Baran, Enrique José
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Ciencias Exactas
Oxidovanadium(IV)
Metvan
DFTcalculations
FTIRspectrum
Human bone and colorectal cancer cell lines
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131026
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131026
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Oxidovanadium(IV)
Metvan
DFTcalculations
FTIRspectrum
Human bone and colorectal cancer cell lines
spellingShingle Ciencias Exactas
Oxidovanadium(IV)
Metvan
DFTcalculations
FTIRspectrum
Human bone and colorectal cancer cell lines
León, Ignacio Esteban
Ruiz, María Carolina
Franca, Carlos Alberto
Parajón Costa, Beatriz Susana
Baran, Enrique José
Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study—Antitumor Action on Human Bone and Colorectal Cancer Cell Lines
topic_facet Ciencias Exactas
Oxidovanadium(IV)
Metvan
DFTcalculations
FTIRspectrum
Human bone and colorectal cancer cell lines
description The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study. The complex was also characterized by a detailed analysis of its infrared spectrum, supported by the theoretical calculations, and also by some data derived from its Raman spectrum. In addition, cytotoxicity studies were performed using human osteosarcoma (MG-63) and human colorectal adenocarcinoma (HT-29) cell lines. The results show that Metvan impaired cell viability of both cancer cell lines in a low concentration range (0.25–5.0 μM).
format Articulo
Articulo
author León, Ignacio Esteban
Ruiz, María Carolina
Franca, Carlos Alberto
Parajón Costa, Beatriz Susana
Baran, Enrique José
author_facet León, Ignacio Esteban
Ruiz, María Carolina
Franca, Carlos Alberto
Parajón Costa, Beatriz Susana
Baran, Enrique José
author_sort León, Ignacio Esteban
title Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study—Antitumor Action on Human Bone and Colorectal Cancer Cell Lines
title_short Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study—Antitumor Action on Human Bone and Colorectal Cancer Cell Lines
title_full Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study—Antitumor Action on Human Bone and Colorectal Cancer Cell Lines
title_fullStr Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study—Antitumor Action on Human Bone and Colorectal Cancer Cell Lines
title_full_unstemmed Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study—Antitumor Action on Human Bone and Colorectal Cancer Cell Lines
title_sort metvan, bis(4,7-dimethyl-1,10-phenanthroline)sulfatooxidovanadium(iv): dft and spectroscopic study—antitumor action on human bone and colorectal cancer cell lines
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/131026
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