Emulsan-Alginate Microspheres as a New Vehicle for Protein Delivery

A solution containing emulsan, a lipoheteropolysaccharide, and calcium was used to produce emulsan-alginate microspheres (EAMs). Optical, scanning electron microscopy and EDX (Energy Dispersive X-ray) analysis of the microspheres suggested different morphologies and compositions, respectively, when...

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Detalles Bibliográficos
Autores principales: Castro, Guillermo Raúl, Bora, Emilia, Panilaitis, Bruce, Kaplan, David I., Khemani, Kishan C., Scholz, Carmen
Formato: Libro Capitulo de libro
Lenguaje:Inglés
Publicado: American Chemical Society 2006
Materias:
Química
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/130967
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-130967
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
spellingShingle Química
Castro, Guillermo Raúl
Bora, Emilia
Panilaitis, Bruce
Kaplan, David I.
Khemani, Kishan C.
Scholz, Carmen
Emulsan-Alginate Microspheres as a New Vehicle for Protein Delivery
topic_facet Química
description A solution containing emulsan, a lipoheteropolysaccharide, and calcium was used to produce emulsan-alginate microspheres (EAMs). Optical, scanning electron microscopy and EDX (Energy Dispersive X-ray) analysis of the microspheres suggested different morphologies and compositions, respectively, when compared with microspheres prepared only from alginate. The EAMs were twice as stable in phosphate solution compared to alginate alone when assessed with blue dextran encapsulation. The EAMs were able to adsorb about twice the amount of BSA (Bovine Serum Albumin) compared to alginate alone. When azo-BSA was adsorbed on the emulsan-alginate microspheres, protein release could be triggered with enzymes. BSA released from the EAMs retained about of 78% of the -helix structure.
format Libro
Capitulo de libro
author Castro, Guillermo Raúl
Bora, Emilia
Panilaitis, Bruce
Kaplan, David I.
Khemani, Kishan C.
Scholz, Carmen
author_facet Castro, Guillermo Raúl
Bora, Emilia
Panilaitis, Bruce
Kaplan, David I.
Khemani, Kishan C.
Scholz, Carmen
author_sort Castro, Guillermo Raúl
title Emulsan-Alginate Microspheres as a New Vehicle for Protein Delivery
title_short Emulsan-Alginate Microspheres as a New Vehicle for Protein Delivery
title_full Emulsan-Alginate Microspheres as a New Vehicle for Protein Delivery
title_fullStr Emulsan-Alginate Microspheres as a New Vehicle for Protein Delivery
title_full_unstemmed Emulsan-Alginate Microspheres as a New Vehicle for Protein Delivery
title_sort emulsan-alginate microspheres as a new vehicle for protein delivery
publisher American Chemical Society
publishDate 2006
url http://sedici.unlp.edu.ar/handle/10915/130967
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AT kaplandavidi emulsanalginatemicrospheresasanewvehicleforproteindelivery
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bdutipo_str Repositorios
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