Systemic and microcirculatory responses to progressive hemorrhage

Objective: To compare systemic hemodynamics with microcirculatory changes at different vascular beds during progressive hemorrhage. Setting: Universitybased research laboratory. Subjects: Twelve anesthetized, mechanically ventilated sheep. Interventions: Sheep were randomly assigned to HEMORRHAGE or...

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Detalles Bibliográficos
Autores principales: Dubin, Arnaldo, Pozo, Mario Omar, Ferrara, Gonzalo, Murias, Gastón, Martins, Enrique Francisco, Canullán, Carlos, Canales, Héctor Saúl, Kanoore Edul, Vanina Siham, Estenssoro, Elisa, Ince, Can
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Ciencias Médicas
Oxygen transport
Blood flow
Hemorrhage
Microcirculation
Intramucosal acidosis
Lactate
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/130950
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-130950
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Oxygen transport
Blood flow
Hemorrhage
Microcirculation
Intramucosal acidosis
Lactate
spellingShingle Ciencias Médicas
Oxygen transport
Blood flow
Hemorrhage
Microcirculation
Intramucosal acidosis
Lactate
Dubin, Arnaldo
Pozo, Mario Omar
Ferrara, Gonzalo
Murias, Gastón
Martins, Enrique Francisco
Canullán, Carlos
Canales, Héctor Saúl
Kanoore Edul, Vanina Siham
Estenssoro, Elisa
Ince, Can
Systemic and microcirculatory responses to progressive hemorrhage
topic_facet Ciencias Médicas
Oxygen transport
Blood flow
Hemorrhage
Microcirculation
Intramucosal acidosis
Lactate
description Objective: To compare systemic hemodynamics with microcirculatory changes at different vascular beds during progressive hemorrhage. Setting: Universitybased research laboratory. Subjects: Twelve anesthetized, mechanically ventilated sheep. Interventions: Sheep were randomly assigned to HEMORRHAGE or CONTROL group. In the HEMORRHAGE group (n = 8), three stepwise bleedings of 5 ml/kg at 30- min intervals were performed to add up 15 ml/kg. In the CONTROL group (n = 4), sheep had the same surgical preparation but were not bled. Measurements and main results: Progressive bleeding decreased cardiac output, and superior mesenteric artery blood flow, and systemic and intestinal oxygen transports from the first step of bleeding whereas systemic and intestinal oxygen consumption remained unchanged. Mean arterial blood pressure, arterial pH and base excess, and intramucosal-arterial PCO2 were only significantly modified in the last step of bleeding. Arterial lactate increased and sublingual, and intestinal serosal and mucosal capillary microvascular flow indexes and red blood cell velocities progressively decreased after the first step of bleeding (3.0 ± 0.1 vs. 2.3 ± 0.4, 3.2 ± 0.2 vs. 2.4 ± 0.6, 3.0 ± 0.0 vs. 2.0 ± 0.2, and 1,082 ± 29 vs. 977 ± 79, 1,042 ± 24 vs. 953 ± 60, 287 ± 65 vs. 262 ± 16 μm/s; P\0.05 for all). Conclusions: Alterations in sublingual, intestinal microcirculation, and arterial lactate simultaneously arose from the first step of bleeding. The microcirculatory changes were identified either by semi-quantitative flow index or by quantitative red blood cell velocity measurements.
format Articulo
Articulo
author Dubin, Arnaldo
Pozo, Mario Omar
Ferrara, Gonzalo
Murias, Gastón
Martins, Enrique Francisco
Canullán, Carlos
Canales, Héctor Saúl
Kanoore Edul, Vanina Siham
Estenssoro, Elisa
Ince, Can
author_facet Dubin, Arnaldo
Pozo, Mario Omar
Ferrara, Gonzalo
Murias, Gastón
Martins, Enrique Francisco
Canullán, Carlos
Canales, Héctor Saúl
Kanoore Edul, Vanina Siham
Estenssoro, Elisa
Ince, Can
author_sort Dubin, Arnaldo
title Systemic and microcirculatory responses to progressive hemorrhage
title_short Systemic and microcirculatory responses to progressive hemorrhage
title_full Systemic and microcirculatory responses to progressive hemorrhage
title_fullStr Systemic and microcirculatory responses to progressive hemorrhage
title_full_unstemmed Systemic and microcirculatory responses to progressive hemorrhage
title_sort systemic and microcirculatory responses to progressive hemorrhage
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/130950
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