The pharmacokinetics of thiamphenicol in lactating cows

The pharmacokinetics of thiamphenicol were studied after intravenous and intramuscular administration of 25 mg/kg body weight in lactating cows. Distribution (t1/2 alpha) and elimination (t1/2 beta) half-lives of 6.10 +/- 1.39 min and 1.60 +/- 0.30 h, respectively, were obtained after intravenous ad...

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Autores principales: Mestorino, Olga Nora, Landoni, María Fabiana, Alt, M., Errecalde, Jorge Oscar
Formato: Articulo
Lenguaje:Inglés
Publicado: 1993
Materias:
Ciencias Veterinarias
Cows
Intramuscular
Intravenous
Lactation
Milk
Pharmacokinetics
Serum
Thiamphenicol
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/130942
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-130942
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Cows
Intramuscular
Intravenous
Lactation
Milk
Pharmacokinetics
Serum
Thiamphenicol
spellingShingle Ciencias Veterinarias
Cows
Intramuscular
Intravenous
Lactation
Milk
Pharmacokinetics
Serum
Thiamphenicol
Mestorino, Olga Nora
Landoni, María Fabiana
Alt, M.
Errecalde, Jorge Oscar
The pharmacokinetics of thiamphenicol in lactating cows
topic_facet Ciencias Veterinarias
Cows
Intramuscular
Intravenous
Lactation
Milk
Pharmacokinetics
Serum
Thiamphenicol
description The pharmacokinetics of thiamphenicol were studied after intravenous and intramuscular administration of 25 mg/kg body weight in lactating cows. Distribution (t1/2 alpha) and elimination (t1/2 beta) half-lives of 6.10 +/- 1.39 min and 1.60 +/- 0.30 h, respectively, were obtained after intravenous administration. The body clearance was 3.9 +/- 0.077 ml/kg per min and the apparent volume of distribution was 1220.79 +/- 256.67 ml/kg. The rate at which thiamphenicol appeared in the milk, as indicated by the penetration half-life (t1/2P) (serum to quarters), was found to be 36.89 +/- 11.14 min. The equivalent elimination half-life (t1/2E) (quarters to serum) from the milk was 3.62 +/- 1.06 h and the peak thiamphenicol concentration in the milk was 23.09 +/- 3.42 micrograms/ml at 2.5 +/- 0.32 h. After intramuscular injection, the elimination half-life was 2.2 +/- 0.40 h, the absorption half-life was 4.02 +/- 1.72 min and the peak concentration in the serum was 30.90 +/- 5.24 micrograms/ml at 23 +/- 8.4 min. The bioavailability after intramuscular administration approached 100%. The penetration half-life was 50.59 +/- 6.87 min, the elimination half-life was 5.91 +/- 4.97 h and the mean peak concentration in the milk was 17.37 +/- 2.20 micrograms/ml at 3.4 +/- 0.22 h.
format Articulo
Articulo
author Mestorino, Olga Nora
Landoni, María Fabiana
Alt, M.
Errecalde, Jorge Oscar
author_facet Mestorino, Olga Nora
Landoni, María Fabiana
Alt, M.
Errecalde, Jorge Oscar
author_sort Mestorino, Olga Nora
title The pharmacokinetics of thiamphenicol in lactating cows
title_short The pharmacokinetics of thiamphenicol in lactating cows
title_full The pharmacokinetics of thiamphenicol in lactating cows
title_fullStr The pharmacokinetics of thiamphenicol in lactating cows
title_full_unstemmed The pharmacokinetics of thiamphenicol in lactating cows
title_sort pharmacokinetics of thiamphenicol in lactating cows
publishDate 1993
url http://sedici.unlp.edu.ar/handle/10915/130942
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