Gene Therapy in the Neuroendocrine System

The implementation of experimental gene therapy in animal models of neuroendocrine diseases is an area of growing interest. In the hypothalamus, restorative gene therapy has been successfully implemented in Brattleboro rats, an arginine vasopressin (AVP) mutant which suffers from diabetes insipidus,...

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Detalles Bibliográficos
Autores principales: Hereñú, Claudia Beatriz, Morel, Gustavo Ramón, Bellini, María José, Reggiani, Paula Cecilia, Sosa, Yolanda Elena, Brown, Oscar Alfredo, Goya, Rodolfo Gustavo, Arzt, Eduardo, Bronstein, Marcello, Guitelman, Mirtha
Formato: Libro Capitulo de libro
Lenguaje:Inglés
Publicado: Karger 2006
Materias:
Biología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/130700
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-130700
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
spellingShingle Biología
Hereñú, Claudia Beatriz
Morel, Gustavo Ramón
Bellini, María José
Reggiani, Paula Cecilia
Sosa, Yolanda Elena
Brown, Oscar Alfredo
Goya, Rodolfo Gustavo
Arzt, Eduardo
Bronstein, Marcello
Guitelman, Mirtha
Gene Therapy in the Neuroendocrine System
topic_facet Biología
description The implementation of experimental gene therapy in animal models of neuroendocrine diseases is an area of growing interest. In the hypothalamus, restorative gene therapy has been successfully implemented in Brattleboro rats, an arginine vasopressin (AVP) mutant which suffers from diabetes insipidus, and in Koletsky (fak/fak) and in Zucker (fa/fa) rats which have leptin receptor mutations that render them obese, hyperphagic and hyperinsulinemic. In the above models, viral vectors expressing AVP, leptin receptor b and proopiomelanocortin, respectively, were stereotaxically injected in the relevant hypothalamic regions. In rats, aging brings about a progressive degeneration and loss of hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons, which are involved in the tonic inhibitory control of prolactin secretion and lactotropic cell proliferation. Stereotaxic injection of an adenoviral vector expressing insulin-like growth factor I corrected their chronic hyperprolactinemia and restored TIDA neuron numbers. Spontaneous intermediate lobe pituitary tumors in a retinoblastoma (Rb) gene mutant mouse were corrected by injection of an adenoviral vector expressing the human Rb cDNA and experimental prolactinomas in rats were partially reduced by intrapituitary injection of an adenoviral vector expressing the HSV1-thymidine kinase suicide gene. These results suggest that further implementation of gene therapy strategies in neuroendocrine models may be highly rewarding.
format Libro
Capitulo de libro
author Hereñú, Claudia Beatriz
Morel, Gustavo Ramón
Bellini, María José
Reggiani, Paula Cecilia
Sosa, Yolanda Elena
Brown, Oscar Alfredo
Goya, Rodolfo Gustavo
Arzt, Eduardo
Bronstein, Marcello
Guitelman, Mirtha
author_facet Hereñú, Claudia Beatriz
Morel, Gustavo Ramón
Bellini, María José
Reggiani, Paula Cecilia
Sosa, Yolanda Elena
Brown, Oscar Alfredo
Goya, Rodolfo Gustavo
Arzt, Eduardo
Bronstein, Marcello
Guitelman, Mirtha
author_sort Hereñú, Claudia Beatriz
title Gene Therapy in the Neuroendocrine System
title_short Gene Therapy in the Neuroendocrine System
title_full Gene Therapy in the Neuroendocrine System
title_fullStr Gene Therapy in the Neuroendocrine System
title_full_unstemmed Gene Therapy in the Neuroendocrine System
title_sort gene therapy in the neuroendocrine system
publisher Karger
publishDate 2006
url http://sedici.unlp.edu.ar/handle/10915/130700
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