Tautomerizable β-ketonitrile copolymers for bone tissue engineering: Studies of biocompatibility and cytotoxicity

β-Ketonitrile tautomeric copolymers have demonstrated tunable hydrophilicity/hydrophobicity properties according to surrounding environment, and mechanical properties similar to those of human bone tissue. Both characteristic properties make them promising candidates as biomaterials for bone tissue...

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Autores principales: Lastra, María Laura, Molinuevo, María Silvina, Giussi, Juan Martín, Allegretti, Patricia Ercilia, Blaszczyk-Lezak, Iwona, Mijangos, Carmen, Cortizo, María Susana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Exactas
Tautomeric copolymer
Bone tissue engineering
Biocompatibility
Cytotoxicity assays
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/130675
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-130675
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Tautomeric copolymer
Bone tissue engineering
Biocompatibility
Cytotoxicity assays
spellingShingle Ciencias Exactas
Tautomeric copolymer
Bone tissue engineering
Biocompatibility
Cytotoxicity assays
Lastra, María Laura
Molinuevo, María Silvina
Giussi, Juan Martín
Allegretti, Patricia Ercilia
Blaszczyk-Lezak, Iwona
Mijangos, Carmen
Cortizo, María Susana
Tautomerizable β-ketonitrile copolymers for bone tissue engineering: Studies of biocompatibility and cytotoxicity
topic_facet Ciencias Exactas
Tautomeric copolymer
Bone tissue engineering
Biocompatibility
Cytotoxicity assays
description β-Ketonitrile tautomeric copolymers have demonstrated tunable hydrophilicity/hydrophobicity properties according to surrounding environment, and mechanical properties similar to those of human bone tissue. Both characteristic properties make them promising candidates as biomaterials for bone tissue engineering. Based on this knowledge we have designed two scaffolds based on β-ketonitrile tautomeric copolymers which differ in chemical composition and surface morphology. Two of them were nanostructured, using an anodized aluminum oxide (AAO) template, and the other two obtained by solvent casting methodology. They were used to evaluate the effect of the composition and their structural modifications on the biocompatibility, cytotoxicity and degradation properties. Our results showed that the nanostructured scaffolds exhibited higher degradation rate by macrophages than casted scaffolds (6 and 2.5% of degradation for nanostructured and casted scaffolds, respectively), a degradation rate compatible with bone regeneration times. We also demonstrated that the β-ketonitrile tautomeric based scaffolds supported osteoblastic cell proliferation and differentiation without cytotoxic effects, suggesting that these biomaterials could be useful in the bone tissue engineering field.
format Articulo
Articulo
author Lastra, María Laura
Molinuevo, María Silvina
Giussi, Juan Martín
Allegretti, Patricia Ercilia
Blaszczyk-Lezak, Iwona
Mijangos, Carmen
Cortizo, María Susana
author_facet Lastra, María Laura
Molinuevo, María Silvina
Giussi, Juan Martín
Allegretti, Patricia Ercilia
Blaszczyk-Lezak, Iwona
Mijangos, Carmen
Cortizo, María Susana
author_sort Lastra, María Laura
title Tautomerizable β-ketonitrile copolymers for bone tissue engineering: Studies of biocompatibility and cytotoxicity
title_short Tautomerizable β-ketonitrile copolymers for bone tissue engineering: Studies of biocompatibility and cytotoxicity
title_full Tautomerizable β-ketonitrile copolymers for bone tissue engineering: Studies of biocompatibility and cytotoxicity
title_fullStr Tautomerizable β-ketonitrile copolymers for bone tissue engineering: Studies of biocompatibility and cytotoxicity
title_full_unstemmed Tautomerizable β-ketonitrile copolymers for bone tissue engineering: Studies of biocompatibility and cytotoxicity
title_sort tautomerizable β-ketonitrile copolymers for bone tissue engineering: studies of biocompatibility and cytotoxicity
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/130675
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