BoLA‑DRB3 gene haplotypes show divergence in native Sudanese cattle from taurine and indicine breeds

Autochthonous Sudanese cattle breeds, namely Baggara for beef and Butana and Kenana for dairy, are characterized by their adaptive characteristics and high performance in hot and dry agroecosystems. They are thus used largely by nomadic and semi-nomadic pastoralists. We analyzed the diversity and g...

Descripción completa

Detalles Bibliográficos
Autores principales: Salim, Bashir, Takeshima, Shin‑nosuke, Nakao, Ryo, Moustafa, Mohamed A. M., Ahmed, Mohamed‑Khair A., Kambal, Sumaya, Mwacharo, Joram M., Alkhaibari, Abeer M., Giovambattista, Guillermo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Veterinarias
Evolution
Genetics
Immunology
Molecular biology
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/130027
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-130027
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Evolution
Genetics
Immunology
Molecular biology
spellingShingle Ciencias Veterinarias
Evolution
Genetics
Immunology
Molecular biology
Salim, Bashir
Takeshima, Shin‑nosuke
Nakao, Ryo
Moustafa, Mohamed A. M.
Ahmed, Mohamed‑Khair A.
Kambal, Sumaya
Mwacharo, Joram M.
Alkhaibari, Abeer M.
Giovambattista, Guillermo
BoLA‑DRB3 gene haplotypes show divergence in native Sudanese cattle from taurine and indicine breeds
topic_facet Ciencias Veterinarias
Evolution
Genetics
Immunology
Molecular biology
description Autochthonous Sudanese cattle breeds, namely Baggara for beef and Butana and Kenana for dairy, are characterized by their adaptive characteristics and high performance in hot and dry agroecosystems. They are thus used largely by nomadic and semi-nomadic pastoralists. We analyzed the diversity and genetic structure of the BoLA-DRB3 gene, a genetic locus linked to the immune response, for the indigenous cattle of Sudan and in the context of the global cattle repository. Blood samples (n = 225) were taken from three indigenous breeds (Baggara; n = 113, Butana; n = 60 and Kenana; n = 52) distributed across six regions of Sudan. Nucleotide sequences were genotyped using the sequence-based typing method. We describe 53 alleles, including seven novel alleles. Principal component analysis (PCA) of the protein pockets implicated in the antigen-binding function of the MHC complex revealed that pockets 4 and 9 (respectively) differentiate Kenana-Baggara and Kenana-Butana breeds from other breeds. Venn analysis of Sudanese, Southeast Asian, European and American cattle breeds with 115 alleles showed 14 were unique to Sudanese breeds. Gene frequency distributions of Baggara cattle showed an even distribution suggesting balancing selection, while the selection index (ω) revealed the presence of diversifying selection in several amino acid sites along the BoLA-DRB3 exon 2 of these native breeds. The results of several PCA were in agreement with clustering patterns observed on the neighbor joining (NJ) trees. These results provide insight into their high survival rate for different tropical diseases and their reproductive capacity in Sudan’s harsh environment.
format Articulo
Articulo
author Salim, Bashir
Takeshima, Shin‑nosuke
Nakao, Ryo
Moustafa, Mohamed A. M.
Ahmed, Mohamed‑Khair A.
Kambal, Sumaya
Mwacharo, Joram M.
Alkhaibari, Abeer M.
Giovambattista, Guillermo
author_facet Salim, Bashir
Takeshima, Shin‑nosuke
Nakao, Ryo
Moustafa, Mohamed A. M.
Ahmed, Mohamed‑Khair A.
Kambal, Sumaya
Mwacharo, Joram M.
Alkhaibari, Abeer M.
Giovambattista, Guillermo
author_sort Salim, Bashir
title BoLA‑DRB3 gene haplotypes show divergence in native Sudanese cattle from taurine and indicine breeds
title_short BoLA‑DRB3 gene haplotypes show divergence in native Sudanese cattle from taurine and indicine breeds
title_full BoLA‑DRB3 gene haplotypes show divergence in native Sudanese cattle from taurine and indicine breeds
title_fullStr BoLA‑DRB3 gene haplotypes show divergence in native Sudanese cattle from taurine and indicine breeds
title_full_unstemmed BoLA‑DRB3 gene haplotypes show divergence in native Sudanese cattle from taurine and indicine breeds
title_sort bola‑drb3 gene haplotypes show divergence in native sudanese cattle from taurine and indicine breeds
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/130027
work_keys_str_mv AT salimbashir boladrb3genehaplotypesshowdivergenceinnativesudanesecattlefromtaurineandindicinebreeds
AT takeshimashinnosuke boladrb3genehaplotypesshowdivergenceinnativesudanesecattlefromtaurineandindicinebreeds
AT nakaoryo boladrb3genehaplotypesshowdivergenceinnativesudanesecattlefromtaurineandindicinebreeds
AT moustafamohamedam boladrb3genehaplotypesshowdivergenceinnativesudanesecattlefromtaurineandindicinebreeds
AT ahmedmohamedkhaira boladrb3genehaplotypesshowdivergenceinnativesudanesecattlefromtaurineandindicinebreeds
AT kambalsumaya boladrb3genehaplotypesshowdivergenceinnativesudanesecattlefromtaurineandindicinebreeds
AT mwacharojoramm boladrb3genehaplotypesshowdivergenceinnativesudanesecattlefromtaurineandindicinebreeds
AT alkhaibariabeerm boladrb3genehaplotypesshowdivergenceinnativesudanesecattlefromtaurineandindicinebreeds
AT giovambattistaguillermo boladrb3genehaplotypesshowdivergenceinnativesudanesecattlefromtaurineandindicinebreeds
bdutipo_str Repositorios
_version_ 1764820452964827136

Ejemplares similares