A Novel Sulfonamidoglycosylation of Glycals

The sulfonamidoglycosylation of benzylated glycals using a catalytic amount of triphenylphosphine hydrobromide proceeded in a highly stereoselective fashion to give the β anomers with good to high yields. This process was demonstrated with D-galactal and D-glucal. Two of the new N-2-(deoxyglycosyl)s...

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Detalles Bibliográficos
Autores principales: Colinas, Pedro Alfonso, Bravo, Rodolfo Daniel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2003
Materias:
Química
Addition reactions
Catalysts
Inhibitors
Sulfones
Pharmaceuticals
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/129282
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-129282
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Addition reactions
Catalysts
Inhibitors
Sulfones
Pharmaceuticals
spellingShingle Química
Addition reactions
Catalysts
Inhibitors
Sulfones
Pharmaceuticals
Colinas, Pedro Alfonso
Bravo, Rodolfo Daniel
A Novel Sulfonamidoglycosylation of Glycals
topic_facet Química
Addition reactions
Catalysts
Inhibitors
Sulfones
Pharmaceuticals
description The sulfonamidoglycosylation of benzylated glycals using a catalytic amount of triphenylphosphine hydrobromide proceeded in a highly stereoselective fashion to give the β anomers with good to high yields. This process was demonstrated with D-galactal and D-glucal. Two of the new N-2-(deoxyglycosyl)sulfonamides were tested as inhibitors of tumor cell growth in vitro and showed antiproliferative properties in the micromolar range.
format Articulo
Articulo
author Colinas, Pedro Alfonso
Bravo, Rodolfo Daniel
author_facet Colinas, Pedro Alfonso
Bravo, Rodolfo Daniel
author_sort Colinas, Pedro Alfonso
title A Novel Sulfonamidoglycosylation of Glycals
title_short A Novel Sulfonamidoglycosylation of Glycals
title_full A Novel Sulfonamidoglycosylation of Glycals
title_fullStr A Novel Sulfonamidoglycosylation of Glycals
title_full_unstemmed A Novel Sulfonamidoglycosylation of Glycals
title_sort novel sulfonamidoglycosylation of glycals
publishDate 2003
url http://sedici.unlp.edu.ar/handle/10915/129282
work_keys_str_mv AT colinaspedroalfonso anovelsulfonamidoglycosylationofglycals
AT bravorodolfodaniel anovelsulfonamidoglycosylationofglycals
AT colinaspedroalfonso novelsulfonamidoglycosylationofglycals
AT bravorodolfodaniel novelsulfonamidoglycosylationofglycals
bdutipo_str Repositorios
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