Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina

Toxoplasmosis, a worldwide distributed zoonosis, can be transmitted congenitally affecting fetuses and developing variable clinical signs. Different Toxoplasma gondii genotypes and infective dose are related factors with different clinical manifestations. Several studies indicate that atypical strai...

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Autores principales: Pardini, Lais Luján, Bernstein, Mariana, Carral, Liliana, Kaufer, Federico, Dellarupe, Andrea, Gos, María Laura, Campero, Lucía María, Moré, Gastón Andrés, Messina, Matías T., Schneider, María Vanessa, Freuler, Cristina, Durlach, Ricardo, Unzaga, Juan Manuel, Venturini, María Cecilia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Ciencias Veterinarias
Toxoplasmosis
Congenital
Humans
Genotypes
Isolates
nPCR-RFLP
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/129248
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-129248
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Toxoplasmosis
Congenital
Humans
Genotypes
Isolates
nPCR-RFLP
spellingShingle Ciencias Veterinarias
Toxoplasmosis
Congenital
Humans
Genotypes
Isolates
nPCR-RFLP
Pardini, Lais Luján
Bernstein, Mariana
Carral, Liliana
Kaufer, Federico
Dellarupe, Andrea
Gos, María Laura
Campero, Lucía María
Moré, Gastón Andrés
Messina, Matías T.
Schneider, María Vanessa
Freuler, Cristina
Durlach, Ricardo
Unzaga, Juan Manuel
Venturini, María Cecilia
Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina
topic_facet Ciencias Veterinarias
Toxoplasmosis
Congenital
Humans
Genotypes
Isolates
nPCR-RFLP
description Toxoplasmosis, a worldwide distributed zoonosis, can be transmitted congenitally affecting fetuses and developing variable clinical signs. Different Toxoplasma gondii genotypes and infective dose are related factors with different clinical manifestations. Several studies indicate that atypical strains could produce more severe clinical manifestations compared to typical strains. Umbilical cord blood (n = 37) and placenta (n = 19) were collected at birth from women with acute T. gondii infection and processed for isolation by mice bioassay. Six isolates were obtained and identified as TgHm14-4Arg, TgHm15-02Arg, TgHm16-01Arg, TgHm16-02Arg, TgHm17-01Arg and TgHm17-02Arg. Three genotypes described previously on Toxo-DB were identified: #138 identified in chickens from Brazil, #182 isolated from eared doves from Brazil, #14 from wallaby kangaroos and chickens from Argentina, chickens from Brazil, Colombia, Chile and Venezuela, cats and dogs from Brazil and Colombia and also coyotes from USA indicating worldwide distribution of these genotypes. Two new allele combinations were obtained showing high genotypes diversity in Argentina. Four of the isolates (TgHm14-4Arg, TgHm15-02Arg, TgHm16-01Arg, TgHm16-02Arg) and two of them (TgHm17-01Arg, TgHm17-02Arg) produced chronic and acute infections in mice, respectively. Until now, seven T. gondii isolates have been obtained from humans in Argentina, and all were atypical or non-clonal genotypes. The identification of atypical strains causing congenital toxoplasmosis and circulating in our region, make important to perform the serological screenings according Argentine Consensus of Toxoplasmosis and to apply and monitoring treatments earlier in pregnancy. To achieve this aim, it is necessary to inform general population about T. gondii infection, diagnostics and control measures. These results should serve to generate awareness about congenital toxoplasmosis in South America.
format Articulo
Articulo
author Pardini, Lais Luján
Bernstein, Mariana
Carral, Liliana
Kaufer, Federico
Dellarupe, Andrea
Gos, María Laura
Campero, Lucía María
Moré, Gastón Andrés
Messina, Matías T.
Schneider, María Vanessa
Freuler, Cristina
Durlach, Ricardo
Unzaga, Juan Manuel
Venturini, María Cecilia
author_facet Pardini, Lais Luján
Bernstein, Mariana
Carral, Liliana
Kaufer, Federico
Dellarupe, Andrea
Gos, María Laura
Campero, Lucía María
Moré, Gastón Andrés
Messina, Matías T.
Schneider, María Vanessa
Freuler, Cristina
Durlach, Ricardo
Unzaga, Juan Manuel
Venturini, María Cecilia
author_sort Pardini, Lais Luján
title Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina
title_short Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina
title_full Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina
title_fullStr Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina
title_full_unstemmed Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina
title_sort congenital human toxoplasmosis caused by non-clonal toxoplasma gondii genotypes in argentina
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/129248
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