Cardiac remodeling and renin-angiotensin system

Myocardial infarction (MI) leads to structural alterations involving the infarcted as well as the non-infarcted areas in a process known as ventricular remodeling. The early phase of remodeling, which starts at the beginning of the MI, is associated with geometric changes and dilation of the infarct...

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Detalles Bibliográficos
Autores principales: González, Germán E., Basso, Nidia, Gelpi, Ricardo Jorge, Morales, Celina
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2009
Materias:
Ciencias Médicas
myocardial infarction
cardiac remodeling
renin-angiotensin system
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/129071
https://pmr.safisiol.org.ar/archive/id/24
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-129071
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
myocardial infarction
cardiac remodeling
renin-angiotensin system
spellingShingle Ciencias Médicas
myocardial infarction
cardiac remodeling
renin-angiotensin system
González, Germán E.
Basso, Nidia
Gelpi, Ricardo Jorge
Morales, Celina
Cardiac remodeling and renin-angiotensin system
topic_facet Ciencias Médicas
myocardial infarction
cardiac remodeling
renin-angiotensin system
description Myocardial infarction (MI) leads to structural alterations involving the infarcted as well as the non-infarcted areas in a process known as ventricular remodeling. The early phase of remodeling, which starts at the beginning of the MI, is associated with geometric changes and dilation of the infarct zone, as a process collectively known as expansion of the scar. Subsequently, this dilation may progress to the whole ventricle and it is associated with myocytes hypertrophy and fibrosis in the remote zones. These structural changes start on during the initial phase of the healing process of the infarction, contribute to ventricular dysfunction, cause a progression to heart failure and increase mortality. The systemic and cardiac renin-angiotensin systems (RAS) are stimulated post-MI and actively participate in ventricular remodeling, favoring the healing process of the infarct area as well as myocytes hypertrophy, fibrosis, and most of the events associated to the remodeling of non-MI zones. In this review, we analyze different general aspects of postmyocardial infarct ventricular remodeling and the activation and participation of the renin- angiotensin system in its evolution.
format Articulo
Revision
author González, Germán E.
Basso, Nidia
Gelpi, Ricardo Jorge
Morales, Celina
author_facet González, Germán E.
Basso, Nidia
Gelpi, Ricardo Jorge
Morales, Celina
author_sort González, Germán E.
title Cardiac remodeling and renin-angiotensin system
title_short Cardiac remodeling and renin-angiotensin system
title_full Cardiac remodeling and renin-angiotensin system
title_fullStr Cardiac remodeling and renin-angiotensin system
title_full_unstemmed Cardiac remodeling and renin-angiotensin system
title_sort cardiac remodeling and renin-angiotensin system
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/129071
https://pmr.safisiol.org.ar/archive/id/24
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AT bassonidia cardiacremodelingandreninangiotensinsystem
AT gelpiricardojorge cardiacremodelingandreninangiotensinsystem
AT moralescelina cardiacremodelingandreninangiotensinsystem
bdutipo_str Repositorios
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