Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus

Previous work has established that the hormone ghrelin engages the hypothalamic-pituitary-adrenal neuroendocrine axis via activation of corticotropin-releasing factor (CRF) neurons of the hypothalamic paraventricular nucleus (PVN). The neuronal circuitry that mediates this effect of ghrelin is curre...

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Autores principales: Cabral, Agustina Soledad, Portiansky, Enrique Leo, Sánchez Jaramillo, Edith, Zigman, Jeffrey M., Perelló, Mario Carlos
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2016
Materias:
Biología
Ciencias Médicas
Stress
Ghrelin
Orexigenic
γ-aminobutyric acid (GABA)
Neuropeptide Y (NPY)
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/128754
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-128754
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Ciencias Médicas
Stress
Ghrelin
Orexigenic
γ-aminobutyric acid (GABA)
Neuropeptide Y (NPY)
spellingShingle Biología
Ciencias Médicas
Stress
Ghrelin
Orexigenic
γ-aminobutyric acid (GABA)
Neuropeptide Y (NPY)
Cabral, Agustina Soledad
Portiansky, Enrique Leo
Sánchez Jaramillo, Edith
Zigman, Jeffrey M.
Perelló, Mario Carlos
Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus
topic_facet Biología
Ciencias Médicas
Stress
Ghrelin
Orexigenic
γ-aminobutyric acid (GABA)
Neuropeptide Y (NPY)
description Previous work has established that the hormone ghrelin engages the hypothalamic-pituitary-adrenal neuroendocrine axis via activation of corticotropin-releasing factor (CRF) neurons of the hypothalamic paraventricular nucleus (PVN). The neuronal circuitry that mediates this effect of ghrelin is currently unknown. Here, we show that ghrelin-induced activation of PVN CRF neurons involved inhibition of γ-aminobutyric acid (GABA) inputs, likely via ghrelin binding sites that were localized at GABAergic terminals within the PVN. While ghrelin activated PVN CRF neurons in the presence of neuropeptide Y (NPY) receptor antagonists or in arcuate nucleus (ARC)-ablated mice, it failed to do it so in mice with ghrelin receptor expression limited to ARC agouti gene related protein (AgRP)/NPY neurons. These data support the notion that ghrelin activates PVN CRF neurons via inhibition of local GABAergic tone, in an ARC-independent manner. Furthermore, these data suggest that the neuronal circuits mediating ghrelin's orexigenic action vs. its role as a stress signal are anatomically dissociated.
format Articulo
Preprint
author Cabral, Agustina Soledad
Portiansky, Enrique Leo
Sánchez Jaramillo, Edith
Zigman, Jeffrey M.
Perelló, Mario Carlos
author_facet Cabral, Agustina Soledad
Portiansky, Enrique Leo
Sánchez Jaramillo, Edith
Zigman, Jeffrey M.
Perelló, Mario Carlos
author_sort Cabral, Agustina Soledad
title Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus
title_short Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus
title_full Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus
title_fullStr Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus
title_full_unstemmed Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus
title_sort ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/128754
work_keys_str_mv AT cabralagustinasoledad ghrelinactivateshypophysiotropiccorticotropinreleasingfactorneuronsindependentlyofthearcuatenucleus
AT portianskyenriqueleo ghrelinactivateshypophysiotropiccorticotropinreleasingfactorneuronsindependentlyofthearcuatenucleus
AT sanchezjaramilloedith ghrelinactivateshypophysiotropiccorticotropinreleasingfactorneuronsindependentlyofthearcuatenucleus
AT zigmanjeffreym ghrelinactivateshypophysiotropiccorticotropinreleasingfactorneuronsindependentlyofthearcuatenucleus
AT perellomariocarlos ghrelinactivateshypophysiotropiccorticotropinreleasingfactorneuronsindependentlyofthearcuatenucleus
bdutipo_str Repositorios
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