Disrupting effect of androgens in postnatal female domestic cats

To test the hypothesis that in domestic cats, postnatal androgens induce sterility, the aims of this study were to describe the reproductive effects and the clinical safety of a postnatal administration of a long term release androgen in this species. Thirteen newborn littermate female kittens were...

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Autores principales: Demaldé, Lucía, López Merlo, Mariana Lucía, Vercellini, María del Rosario, Barbeito, Claudio Gustavo, Fernández, Patricia Elena, Gobello, María Cristina
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Veterinarias
Postnatal
Testosterone
Anovulation
Endocrine disruption
Felid
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/128723
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-128723
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Postnatal
Testosterone
Anovulation
Endocrine disruption
Felid
spellingShingle Ciencias Veterinarias
Postnatal
Testosterone
Anovulation
Endocrine disruption
Felid
Demaldé, Lucía
López Merlo, Mariana Lucía
Vercellini, María del Rosario
Barbeito, Claudio Gustavo
Fernández, Patricia Elena
Gobello, María Cristina
Disrupting effect of androgens in postnatal female domestic cats
topic_facet Ciencias Veterinarias
Postnatal
Testosterone
Anovulation
Endocrine disruption
Felid
description To test the hypothesis that in domestic cats, postnatal androgens induce sterility, the aims of this study were to describe the reproductive effects and the clinical safety of a postnatal administration of a long term release androgen in this species. Thirteen newborn littermate female kittens were randomly assigned to one of the following treatment groups within the first 24h of birth: testosterone enanthate 12.5mg sc (TE; n=8) or Placebo (PL; n=5). The animals were subsequently assessed for fecal sexual hormones until puberty was attained and subsequently when matings occurred. After 21 days, ovulation and gestation were diagnosed. All queens were subsequently ovario-hysterectomized. Fecal testosterone concentrations differed between the treatment groups throughout the study period (P 0.1). While all the females were receptive during the pubertal estrus (P>0.1), two TE (2/8) compared with all (5/5) females of the PL group had ovulations (P<0.05). Only one (1/2) compared with three (3/5) of the queens of the TE and PL groups, respectively became pregnant. All kittens of the TE group had transient clitoral enlargement. Anovulatory TE-treated cats had no corpus luteum, and a significant diminution of the endometrial glands as well as of the height of the uterine epithelium. It is concluded that, in domestic cats, a single postnatal supra-physiological dose of testosterone caused a large proportion of queens to be anovulatory and there were also histological endometrial abnormalities that also occurred with this treatment that were accompanied by mild and transient side effects.
format Articulo
Preprint
author Demaldé, Lucía
López Merlo, Mariana Lucía
Vercellini, María del Rosario
Barbeito, Claudio Gustavo
Fernández, Patricia Elena
Gobello, María Cristina
author_facet Demaldé, Lucía
López Merlo, Mariana Lucía
Vercellini, María del Rosario
Barbeito, Claudio Gustavo
Fernández, Patricia Elena
Gobello, María Cristina
author_sort Demaldé, Lucía
title Disrupting effect of androgens in postnatal female domestic cats
title_short Disrupting effect of androgens in postnatal female domestic cats
title_full Disrupting effect of androgens in postnatal female domestic cats
title_fullStr Disrupting effect of androgens in postnatal female domestic cats
title_full_unstemmed Disrupting effect of androgens in postnatal female domestic cats
title_sort disrupting effect of androgens in postnatal female domestic cats
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/128723
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