Aging and rejuvenation - a modular epigenome model

The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understandin...

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Detalles Bibliográficos
Autores principales: Chiavellini, Priscila, Canatelli Mallat, Martina, Lehmann, Marianne, Gallardo, María Emilia, Hereñú, Claudia B., Cordeiro, José L., Clement, James P., Goya, Rodolfo Gustavo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Bioquímica
Aging
DNA methylation
Epigenetic clock
Rejuvenation
Cell reprogramming
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/128713
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-128713
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Aging
DNA methylation
Epigenetic clock
Rejuvenation
Cell reprogramming
spellingShingle Bioquímica
Aging
DNA methylation
Epigenetic clock
Rejuvenation
Cell reprogramming
Chiavellini, Priscila
Canatelli Mallat, Martina
Lehmann, Marianne
Gallardo, María Emilia
Hereñú, Claudia B.
Cordeiro, José L.
Clement, James P.
Goya, Rodolfo Gustavo
Aging and rejuvenation - a modular epigenome model
topic_facet Bioquímica
Aging
DNA methylation
Epigenetic clock
Rejuvenation
Cell reprogramming
description The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understanding of postnatal development, giving rise to the emerging view that the epigenome is the driver of aging. The idea was significantly strengthened by the converging discovery that DNA methylation (DNAm) at specific CpG sites could be used as a highly accurate biomarker of age defined by an algorithm known as the Horvath clock. It was at this point where epigenetic rejuvenation came into play as a strategy to reveal to what extent biological age can be set back by making the clock tick backwards. Initial evidence suggests that when the clock is forced to tick backwards in vivo, it is only able to drag the phenotype to a partially rejuvenated condition. In order to explain the results, a bimodular epigenome is proposed, where module A represents the DNAm clock component and module B the remainder of the epigenome. Epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging.
format Articulo
Articulo
author Chiavellini, Priscila
Canatelli Mallat, Martina
Lehmann, Marianne
Gallardo, María Emilia
Hereñú, Claudia B.
Cordeiro, José L.
Clement, James P.
Goya, Rodolfo Gustavo
author_facet Chiavellini, Priscila
Canatelli Mallat, Martina
Lehmann, Marianne
Gallardo, María Emilia
Hereñú, Claudia B.
Cordeiro, José L.
Clement, James P.
Goya, Rodolfo Gustavo
author_sort Chiavellini, Priscila
title Aging and rejuvenation - a modular epigenome model
title_short Aging and rejuvenation - a modular epigenome model
title_full Aging and rejuvenation - a modular epigenome model
title_fullStr Aging and rejuvenation - a modular epigenome model
title_full_unstemmed Aging and rejuvenation - a modular epigenome model
title_sort aging and rejuvenation - a modular epigenome model
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/128713
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