Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative

Whooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccinati...

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Detalles Bibliográficos
Autores principales: Feng, Ye, Chiu, Cheng-Hsun, Heininger, Ulrich, Hozbor, Daniela Flavia, Tan, Tina Q., Wirsing von König, Carl-Heinz
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Biología
Pertussis
Macrolide
Resistance
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/128427
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-128427
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Pertussis
Macrolide
Resistance
spellingShingle Biología
Pertussis
Macrolide
Resistance
Feng, Ye
Chiu, Cheng-Hsun
Heininger, Ulrich
Hozbor, Daniela Flavia
Tan, Tina Q.
Wirsing von König, Carl-Heinz
Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
topic_facet Biología
Pertussis
Macrolide
Resistance
description Whooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccination. Macrolides such as erythromycin and azithromycin are the drugs of primary choice for treatment. In this personal view, we call for attention to macrolide-resistant B. pertussis (MRBP), which has emerged and prevailed in mainland China for years and are exclusively mediated by mutations in the 23S rRNA gene. Whether the prevalence of MRBP in China results from overuse of azithromycin in clinical medicine remains unknown. The incidence of MRBP is low in other countries, but this could be a technical illusion since China employs culture as the mainstream diagnostic method whereas nucleic-acid amplification test being widely used in other countries fail to test antimicrobial susceptibility. Given the increasingly frequent global travel that facilitates microbial transmission worldwide, there is a pressing need to perform international surveillance on MRBP to prevent the potential circulation of the organism. Finding alternative agents that possess good activity against B. pertussis is also urgently required.
format Articulo
Articulo
author Feng, Ye
Chiu, Cheng-Hsun
Heininger, Ulrich
Hozbor, Daniela Flavia
Tan, Tina Q.
Wirsing von König, Carl-Heinz
author_facet Feng, Ye
Chiu, Cheng-Hsun
Heininger, Ulrich
Hozbor, Daniela Flavia
Tan, Tina Q.
Wirsing von König, Carl-Heinz
author_sort Feng, Ye
title Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_short Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_full Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_fullStr Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_full_unstemmed Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_sort emerging macrolide resistance in bordetella pertussis in mainland china: findings and warning from the global pertussis initiative
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/128427
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bdutipo_str Repositorios
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