Biosynthesis of anti-HCV compounds using thermophilic microorganisms

This work describes the application of thermophilic microorganisms for obtaining 6-halogenated purine nucleosides. Biosynthesis of 6-chloropurine-2′-deoxyriboside and 6-chloropurine riboside was achieved by Geobacillus stearothermophilus CECT 43 with a conversion of 90% and 68%, respectively. Furthe...

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Detalles Bibliográficos
Autores principales:	Rivero, Cintia W., De Benedetti, Eliana C., Sambeth, Jorge Enrique, Lozano, Mario Enrique, Trelles, Jorge A.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Química Geobacillus stearothermophilus Nucleoside analogues Green chemistry Entrapment immobilization
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/128236
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-128236
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Geobacillus stearothermophilus Nucleoside analogues Green chemistry Entrapment immobilization
spellingShingle	Química Geobacillus stearothermophilus Nucleoside analogues Green chemistry Entrapment immobilization Rivero, Cintia W. De Benedetti, Eliana C. Sambeth, Jorge Enrique Lozano, Mario Enrique Trelles, Jorge A. Biosynthesis of anti-HCV compounds using thermophilic microorganisms
topic_facet	Química Geobacillus stearothermophilus Nucleoside analogues Green chemistry Entrapment immobilization
description	This work describes the application of thermophilic microorganisms for obtaining 6-halogenated purine nucleosides. Biosynthesis of 6-chloropurine-2′-deoxyriboside and 6-chloropurine riboside was achieved by Geobacillus stearothermophilus CECT 43 with a conversion of 90% and 68%, respectively. Furthermore, the selected microorganism was satisfactorily stabilized by immobilization in an agarose matrix. This biocatalyst can be reused at least 70 times without significant loss of activity, obtaining 379 mg/L of 6-chloropurine-2′-deoxyriboside. The obtained compounds can be used as antiviral agents.
format	Articulo Articulo
author	Rivero, Cintia W. De Benedetti, Eliana C. Sambeth, Jorge Enrique Lozano, Mario Enrique Trelles, Jorge A.
author_facet	Rivero, Cintia W. De Benedetti, Eliana C. Sambeth, Jorge Enrique Lozano, Mario Enrique Trelles, Jorge A.
author_sort	Rivero, Cintia W.
title	Biosynthesis of anti-HCV compounds using thermophilic microorganisms
title_short	Biosynthesis of anti-HCV compounds using thermophilic microorganisms
title_full	Biosynthesis of anti-HCV compounds using thermophilic microorganisms
title_fullStr	Biosynthesis of anti-HCV compounds using thermophilic microorganisms
title_full_unstemmed	Biosynthesis of anti-HCV compounds using thermophilic microorganisms
title_sort	biosynthesis of anti-hcv compounds using thermophilic microorganisms
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/128236
work_keys_str_mv	AT riverocintiaw biosynthesisofantihcvcompoundsusingthermophilicmicroorganisms AT debenedettielianac biosynthesisofantihcvcompoundsusingthermophilicmicroorganisms AT sambethjorgeenrique biosynthesisofantihcvcompoundsusingthermophilicmicroorganisms AT lozanomarioenrique biosynthesisofantihcvcompoundsusingthermophilicmicroorganisms AT trellesjorgea biosynthesisofantihcvcompoundsusingthermophilicmicroorganisms
bdutipo_str	Repositorios
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Biosynthesis of anti-HCV compounds using thermophilic microorganisms

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