Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents
In the search for new therapeutic tools against tuberculosis and to further address the therapeutic potential of pyridine-2-thiol 1-oxide (Hmpo) metal complexes, two new octahedral [M(III)(mpo)3] complexes, with M = Ga or Bi, were synthesized and characterized in the solid state and in solution. Att...
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Autores principales: | , , , , , , , |
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Formato: | Articulo |
Lenguaje: | Inglés |
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2014
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/128228 |
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I19-R120-10915-128228 |
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institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Química Gallium(III) Bismuth(III) Iron(III) Mycobacterium tuberculosis Pyridine-2-thiol 1-oxide compounds |
spellingShingle |
Química Gallium(III) Bismuth(III) Iron(III) Mycobacterium tuberculosis Pyridine-2-thiol 1-oxide compounds Machado, Ignacio Raúl Marino, Leonardo B. Demoro, Bruno Echeverría, Gustavo Alberto Piro, Oscar Enrique Fujimura Leite, Clarice Queico Pavan, Fernando Rogério Gambino, Dinorah Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents |
topic_facet |
Química Gallium(III) Bismuth(III) Iron(III) Mycobacterium tuberculosis Pyridine-2-thiol 1-oxide compounds |
description |
In the search for new therapeutic tools against tuberculosis and to further address the therapeutic potential of pyridine-2-thiol 1-oxide (Hmpo) metal complexes, two new octahedral [M(III)(mpo)3] complexes, with M = Ga or Bi, were synthesized and characterized in the solid state and in solution. Attempts to crystallize [Ga(III)(mpo)3] in CH2Cl2 led to single crystals of the reaction product [GaCl(mpo)2], where the gallium(III) ion is in a square basis pyramidal environment, trans-coordinated at the basis to two pyridine-2-thiolato 1-oxide anions acting as bidentate ligands through their oxygen and sulfur atoms. The biological activity of the new [M(III)(mpo)3] complexes together with that of the previously reported Fe(III) analogous compound and the pyridine-2-thiol 1-oxide sodium salt (Na mpo) was evaluated on Mycobacterium tuberculosis. The compounds showed excellent activity, both in the standard strain H37Rv ATCC 27294 (pan-susceptible) and in five clinical isolates that are resistant to the standard first-line anti-tuberculosis drugs isoniazid and rifampicin. These pyridine-2-thiol 1-oxide derivatives are promising compounds for the treatment of resistant tuberculosis. |
format |
Articulo Articulo |
author |
Machado, Ignacio Raúl Marino, Leonardo B. Demoro, Bruno Echeverría, Gustavo Alberto Piro, Oscar Enrique Fujimura Leite, Clarice Queico Pavan, Fernando Rogério Gambino, Dinorah |
author_facet |
Machado, Ignacio Raúl Marino, Leonardo B. Demoro, Bruno Echeverría, Gustavo Alberto Piro, Oscar Enrique Fujimura Leite, Clarice Queico Pavan, Fernando Rogério Gambino, Dinorah |
author_sort |
Machado, Ignacio Raúl |
title |
Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents |
title_short |
Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents |
title_full |
Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents |
title_fullStr |
Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents |
title_full_unstemmed |
Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents |
title_sort |
bioactivity of pyridine-2-thiolato-1-oxide metal complexes: bi(iii), fe(iii) and ga(iii) complexes as potent anti-mycobacterium tuberculosis prospective agents |
publishDate |
2014 |
url |
http://sedici.unlp.edu.ar/handle/10915/128228 |
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