Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents

In the search for new therapeutic tools against tuberculosis and to further address the therapeutic potential of pyridine-2-thiol 1-oxide (Hmpo) metal complexes, two new octahedral [M(III)(mpo)3] complexes, with M = Ga or Bi, were synthesized and characterized in the solid state and in solution. Att...

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Autores principales: Machado, Ignacio Raúl, Marino, Leonardo B., Demoro, Bruno, Echeverría, Gustavo Alberto, Piro, Oscar Enrique, Fujimura Leite, Clarice Queico, Pavan, Fernando Rogério, Gambino, Dinorah
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Química
Gallium(III)
Bismuth(III)
Iron(III)
Mycobacterium tuberculosis
Pyridine-2-thiol 1-oxide compounds
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/128228
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-128228
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Gallium(III)
Bismuth(III)
Iron(III)
Mycobacterium tuberculosis
Pyridine-2-thiol 1-oxide compounds
spellingShingle Química
Gallium(III)
Bismuth(III)
Iron(III)
Mycobacterium tuberculosis
Pyridine-2-thiol 1-oxide compounds
Machado, Ignacio Raúl
Marino, Leonardo B.
Demoro, Bruno
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Fujimura Leite, Clarice Queico
Pavan, Fernando Rogério
Gambino, Dinorah
Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents
topic_facet Química
Gallium(III)
Bismuth(III)
Iron(III)
Mycobacterium tuberculosis
Pyridine-2-thiol 1-oxide compounds
description In the search for new therapeutic tools against tuberculosis and to further address the therapeutic potential of pyridine-2-thiol 1-oxide (Hmpo) metal complexes, two new octahedral [M(III)(mpo)3] complexes, with M = Ga or Bi, were synthesized and characterized in the solid state and in solution. Attempts to crystallize [Ga(III)(mpo)3] in CH2Cl2 led to single crystals of the reaction product [GaCl(mpo)2], where the gallium(III) ion is in a square basis pyramidal environment, trans-coordinated at the basis to two pyridine-2-thiolato 1-oxide anions acting as bidentate ligands through their oxygen and sulfur atoms. The biological activity of the new [M(III)(mpo)3] complexes together with that of the previously reported Fe(III) analogous compound and the pyridine-2-thiol 1-oxide sodium salt (Na mpo) was evaluated on Mycobacterium tuberculosis. The compounds showed excellent activity, both in the standard strain H37Rv ATCC 27294 (pan-susceptible) and in five clinical isolates that are resistant to the standard first-line anti-tuberculosis drugs isoniazid and rifampicin. These pyridine-2-thiol 1-oxide derivatives are promising compounds for the treatment of resistant tuberculosis.
format Articulo
Articulo
author Machado, Ignacio Raúl
Marino, Leonardo B.
Demoro, Bruno
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Fujimura Leite, Clarice Queico
Pavan, Fernando Rogério
Gambino, Dinorah
author_facet Machado, Ignacio Raúl
Marino, Leonardo B.
Demoro, Bruno
Echeverría, Gustavo Alberto
Piro, Oscar Enrique
Fujimura Leite, Clarice Queico
Pavan, Fernando Rogério
Gambino, Dinorah
author_sort Machado, Ignacio Raúl
title Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents
title_short Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents
title_full Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents
title_fullStr Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents
title_full_unstemmed Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents
title_sort bioactivity of pyridine-2-thiolato-1-oxide metal complexes: bi(iii), fe(iii) and ga(iii) complexes as potent anti-mycobacterium tuberculosis prospective agents
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/128228
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