The critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review

Toll-like receptors (TLRs) constitute an important mechanism in the activation of innate immune cells including monocytes, macrophages and dendritic cells. Macrophage activation by TLRs is pivotal in the initiation of the rapid expression of pro-inflammatory cytokines TNF, IL-1β and IL-6 while promo...

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Autores principales: Jiménez Dalmaroni, Maximiliano, Gerswhin, M. Eric, Adamopoulos, Iannis E.
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2016
Materias:
Bioquímica
Ciencias Médicas
Toll-like receptors
Rheumatoid arthritis
Innate immunity
Osteoclasts
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/128042
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-128042
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Ciencias Médicas
Toll-like receptors
Rheumatoid arthritis
Innate immunity
Osteoclasts
spellingShingle Bioquímica
Ciencias Médicas
Toll-like receptors
Rheumatoid arthritis
Innate immunity
Osteoclasts
Jiménez Dalmaroni, Maximiliano
Gerswhin, M. Eric
Adamopoulos, Iannis E.
The critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review
topic_facet Bioquímica
Ciencias Médicas
Toll-like receptors
Rheumatoid arthritis
Innate immunity
Osteoclasts
description Toll-like receptors (TLRs) constitute an important mechanism in the activation of innate immune cells including monocytes, macrophages and dendritic cells. Macrophage activation by TLRs is pivotal in the initiation of the rapid expression of pro-inflammatory cytokines TNF, IL-1β and IL-6 while promoting Th17 responses, all of which play critical roles in autoimmunity. Surprisingly, in inflammatory arthritis, activation of specific TLRs can not only induce but also inhibit cellular processes associated with bone destruction. The intercellular and intracellular orchestration of signals from different TLRs, their endogenous or microbial ligands and accessory molecules determine the activating or inhibitory responses. Herein, we review the TLR-mediated activation of innate immune cells in their activation and differentiation to osteoclasts and the capacity of these signals to contribute to bone destruction in arthritis. Detailed understanding of the opposing mechanisms of TLRs in the induction and suppression of cellular processes in arthritis may pave the way to develop novel therapies to treat autoimmunity.
format Articulo
Preprint
author Jiménez Dalmaroni, Maximiliano
Gerswhin, M. Eric
Adamopoulos, Iannis E.
author_facet Jiménez Dalmaroni, Maximiliano
Gerswhin, M. Eric
Adamopoulos, Iannis E.
author_sort Jiménez Dalmaroni, Maximiliano
title The critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review
title_short The critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review
title_full The critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review
title_fullStr The critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review
title_full_unstemmed The critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review
title_sort critical role of toll-like receptors - from microbial recognition to autoimmunity: a comprehensive review
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/128042
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