OKB, a novel family of brain-gut neuropeptides from insects

In insects, neuropeptides play a central role in the control of most physiological processes. The knowledge and characterization of new neuropeptide families, is of interest on the fields of Genetics, Genomics, Neurobiology, Endocrinology and Evolution. This knowledge also provides the tools for the...

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Detalles Bibliográficos
Autores principales: Sterkel, Marcos, Oliveira, Pedro L., Urlaub, Henning, Hernández Martínez, Salvador, Rivera Pomar, Rolando Víctor, Ons, Sheila
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Biología
Neuropeptides
Orcokinins
Insects
Rhodnius prolixus
Chagas’ disease
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127976
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127976
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Neuropeptides
Orcokinins
Insects
Rhodnius prolixus
Chagas’ disease
spellingShingle Biología
Neuropeptides
Orcokinins
Insects
Rhodnius prolixus
Chagas’ disease
Sterkel, Marcos
Oliveira, Pedro L.
Urlaub, Henning
Hernández Martínez, Salvador
Rivera Pomar, Rolando Víctor
Ons, Sheila
OKB, a novel family of brain-gut neuropeptides from insects
topic_facet Biología
Neuropeptides
Orcokinins
Insects
Rhodnius prolixus
Chagas’ disease
description In insects, neuropeptides play a central role in the control of most physiological processes. The knowledge and characterization of new neuropeptide families, is of interest on the fields of Genetics, Genomics, Neurobiology, Endocrinology and Evolution. This knowledge also provides the tools for the design of peptidomimetics, pseudopeptides or small molecules, capable of disrupting the physiological processes regulated by the signaling molecules and their receptors. This is a promising target for a novel generation of insecticides. Using database searches, mass spectrometry and RACE-PCR, we identified a neuropeptide precursor transcript encoding a new family of insect neuropeptides in the hemipteran Rhodnius prolixus. We named this precursor Orcokinin B, because is originated by the alternative splicing of the Orcokinin gen. EST and genomic data suggests that Orcokinin B is expressed in the nervous system and gut from several insect species, with the exception of Drosophila sp. (Diptera) and Acyirthosiphon pisum (Hemiptera). Mass spectrometry and RT-PCR confirmed the expression of Orcokinin B in brain and anterior midgut of R. prolixus. Furthermore, we identified orthologues of this new family of peptides in genomic and EST databases from Arachnids and Crustaceans.
format Articulo
Articulo
author Sterkel, Marcos
Oliveira, Pedro L.
Urlaub, Henning
Hernández Martínez, Salvador
Rivera Pomar, Rolando Víctor
Ons, Sheila
author_facet Sterkel, Marcos
Oliveira, Pedro L.
Urlaub, Henning
Hernández Martínez, Salvador
Rivera Pomar, Rolando Víctor
Ons, Sheila
author_sort Sterkel, Marcos
title OKB, a novel family of brain-gut neuropeptides from insects
title_short OKB, a novel family of brain-gut neuropeptides from insects
title_full OKB, a novel family of brain-gut neuropeptides from insects
title_fullStr OKB, a novel family of brain-gut neuropeptides from insects
title_full_unstemmed OKB, a novel family of brain-gut neuropeptides from insects
title_sort okb, a novel family of brain-gut neuropeptides from insects
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/127976
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