Ag-NOR staining and satellite association in bone marrow cells from patients with mycosis fungoides

Silver staining of nucleolus organizing regions (Ag-NORs) of acrocentric chromosomes and the frequency of satellite association (SA) in bone marrow (BM) cells from 7 patients with mycosis fungoides (MF), were studied. BM samples of 7 normal healthy individuals were taken as controls. The mean number...

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Autores principales: Pedrazzini, Estela Maris, Slavutsky, Irma
Formato: Articulo
Lenguaje:Inglés
Publicado: 1995
Materias:
Biología
Bone Marrow Cells
Mycosis Fungoides
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127822
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127822
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Bone Marrow Cells
Mycosis Fungoides
spellingShingle Biología
Bone Marrow Cells
Mycosis Fungoides
Pedrazzini, Estela Maris
Slavutsky, Irma
Ag-NOR staining and satellite association in bone marrow cells from patients with mycosis fungoides
topic_facet Biología
Bone Marrow Cells
Mycosis Fungoides
description Silver staining of nucleolus organizing regions (Ag-NORs) of acrocentric chromosomes and the frequency of satellite association (SA) in bone marrow (BM) cells from 7 patients with mycosis fungoides (MF), were studied. BM samples of 7 normal healthy individuals were taken as controls. The mean number of Ag-NORs per metaphase was increased in patients (7.20 +/- 0.25) compared with controls (5.40 +/- 0.16) (p < 0.002), related with the increase of the D group. Moreover, a significant higher percentage of Ag-NOR positive cells in patients (71.7 +/- 3.9) than controls (48.0 +/- 7.8) (p < 0.02), was seen. The analysis of SA revealed a significant increase in the percentage of cells with 1-2 association pairs (ASPs) in patients with respect to their controls (p < 0.05), and a trend to a decrease in the percentage of cells without ASPs. Furthermore, a correlation between the number of Ag-NORs and the mean of ASPs per cell was also found for patients (rk = 0.65; p < 0.05). These results may be associated with a certain degree of immaturity, a high proliferative activity and modifications of the growth rate of BM cells in MF patients.
format Articulo
Articulo
author Pedrazzini, Estela Maris
Slavutsky, Irma
author_facet Pedrazzini, Estela Maris
Slavutsky, Irma
author_sort Pedrazzini, Estela Maris
title Ag-NOR staining and satellite association in bone marrow cells from patients with mycosis fungoides
title_short Ag-NOR staining and satellite association in bone marrow cells from patients with mycosis fungoides
title_full Ag-NOR staining and satellite association in bone marrow cells from patients with mycosis fungoides
title_fullStr Ag-NOR staining and satellite association in bone marrow cells from patients with mycosis fungoides
title_full_unstemmed Ag-NOR staining and satellite association in bone marrow cells from patients with mycosis fungoides
title_sort ag-nor staining and satellite association in bone marrow cells from patients with mycosis fungoides
publishDate 1995
url http://sedici.unlp.edu.ar/handle/10915/127822
work_keys_str_mv AT pedrazziniestelamaris agnorstainingandsatelliteassociationinbonemarrowcellsfrompatientswithmycosisfungoides
AT slavutskyirma agnorstainingandsatelliteassociationinbonemarrowcellsfrompatientswithmycosisfungoides
bdutipo_str Repositorios
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