Physiological role of hormone ouabain

Ouabain, a substance obtained from plant extracts, has been long known as cardiotonic, as well as by its high affinity to the Na-K- ATPase pump. The recent finding that ouabain is endogenously expressed in mammals has prompted research to determine its role as a hormone. We have shown that, in a phy...

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Detalles Bibliográficos
Autores principales:	Cereijido, M., Ponce, A., Larre, M. I., Castillo, A., Hinojosa, L.
Formato:	Articulo Revision
Lenguaje:	Inglés
Publicado:	2015
Materias:	Ciencias Médicas ouabain epithelia tight junctions gap junctions connexins cancer
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/127779 https://pmr.safisiol.org.ar/archive/id/78
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-127779
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas ouabain epithelia tight junctions gap junctions connexins cancer
spellingShingle	Ciencias Médicas ouabain epithelia tight junctions gap junctions connexins cancer Cereijido, M. Ponce, A. Larre, M. I. Castillo, A. Hinojosa, L. Physiological role of hormone ouabain
topic_facet	Ciencias Médicas ouabain epithelia tight junctions gap junctions connexins cancer
description	Ouabain, a substance obtained from plant extracts, has been long known as cardiotonic, as well as by its high affinity to the Na-K- ATPase pump. The recent finding that ouabain is endogenously expressed in mammals has prompted research to determine its role as a hormone. We have shown that, in a physiological level (10 nM), it influences on three important features of epithelial physiology related to cell to cell contacts: (1) It modifies the Tight Junction integrity, as reflected by an increase in the Transepithelial Electrical Resistance (TER) of mature monolayers of MDCK cells. (2) It speeds up ciliogenesis, a feature closely related to epithelial (Apical/Basolateral) polarity and (3) It triggers Gap Junctional Intercellular Communication (GJIC). Since lack of GJIC has been associated to cancer, ouabain may be an interesting player on this issue.
format	Articulo Revision
author	Cereijido, M. Ponce, A. Larre, M. I. Castillo, A. Hinojosa, L.
author_facet	Cereijido, M. Ponce, A. Larre, M. I. Castillo, A. Hinojosa, L.
author_sort	Cereijido, M.
title	Physiological role of hormone ouabain
title_short	Physiological role of hormone ouabain
title_full	Physiological role of hormone ouabain
title_fullStr	Physiological role of hormone ouabain
title_full_unstemmed	Physiological role of hormone ouabain
title_sort	physiological role of hormone ouabain
publishDate	2015
url	http://sedici.unlp.edu.ar/handle/10915/127779 https://pmr.safisiol.org.ar/archive/id/78
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bdutipo_str	Repositorios
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Physiological role of hormone ouabain

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