Metastatic dissemination with special emphasis on breast cancer cutaneous metastases

Metastatic development is a complex, multistage process involving modulation of cell phenotype, cell migration, and dynamic homeotypic as well as heterotypic cell-cell interactions. In breast cancer, MUC1 mucin has been emerging as a key molecule involved in metastasis. MUC1 is a large transmembrane...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Luna, Amalia, Segal-Eiras, Amada, Croce, María Virginia
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Médicas
metastases
cutaneous metastases
breast cancer
MUC1
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127763
https://pmr.safisiol.org.ar/wp-content/uploads/2022/07/vol_8_3.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127763
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
metastases
cutaneous metastases
breast cancer
MUC1
spellingShingle Ciencias Médicas
metastases
cutaneous metastases
breast cancer
MUC1
Luna, Amalia
Segal-Eiras, Amada
Croce, María Virginia
Metastatic dissemination with special emphasis on breast cancer cutaneous metastases
topic_facet Ciencias Médicas
metastases
cutaneous metastases
breast cancer
MUC1
description Metastatic development is a complex, multistage process involving modulation of cell phenotype, cell migration, and dynamic homeotypic as well as heterotypic cell-cell interactions. In breast cancer, MUC1 mucin has been emerging as a key molecule involved in metastasis. MUC1 is a large transmembrane glycoprotein expressed by mammary normal epithelial cells but it is overexpressed and underglycosylated in cancer cells. Cutaneous metastasis is a neoplastic lesion localized at the dermis or subcutaneous cellular tissue, which is not contiguous to the primary tumor, with an overall incidence of 5.3%. The most common tumor to metastasize to the skin is breast cancer with an incidence of 24%. We present a minireview on metastatic dissemination with special emphasis on breast cancer cutaneous metastases and the role that MUC1 plays on it.
format Articulo
Revision
author Luna, Amalia
Segal-Eiras, Amada
Croce, María Virginia
author_facet Luna, Amalia
Segal-Eiras, Amada
Croce, María Virginia
author_sort Luna, Amalia
title Metastatic dissemination with special emphasis on breast cancer cutaneous metastases
title_short Metastatic dissemination with special emphasis on breast cancer cutaneous metastases
title_full Metastatic dissemination with special emphasis on breast cancer cutaneous metastases
title_fullStr Metastatic dissemination with special emphasis on breast cancer cutaneous metastases
title_full_unstemmed Metastatic dissemination with special emphasis on breast cancer cutaneous metastases
title_sort metastatic dissemination with special emphasis on breast cancer cutaneous metastases
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/127763
https://pmr.safisiol.org.ar/wp-content/uploads/2022/07/vol_8_3.pdf
work_keys_str_mv AT lunaamalia metastaticdisseminationwithspecialemphasisonbreastcancercutaneousmetastases
AT segaleirasamada metastaticdisseminationwithspecialemphasisonbreastcancercutaneousmetastases
AT crocemariavirginia metastaticdisseminationwithspecialemphasisonbreastcancercutaneousmetastases
bdutipo_str Repositorios
_version_ 1764820452313661440

Ejemplares similares