The tango between pka and camkii signaling in cardiac pacemaker cells

The sinoatrial node is the primary pacemaker that controls the heart rate under normal conditions. Although the heart rate was originally measured thousands of years ago, the mechanisms that control the spontaneous beating of the sinoatrial node (SAN) are still under debate. In the last century, SAN...

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Autor principal: Yaniv, Yael
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2016
Materias:
Bioquímica
Coupled-clock system
Mathematical modeling
Pacemaker
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127651
https://pmr.safisiol.org.ar/archive/id/90
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127651
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Coupled-clock system
Mathematical modeling
Pacemaker
spellingShingle Bioquímica
Coupled-clock system
Mathematical modeling
Pacemaker
Yaniv, Yael
The tango between pka and camkii signaling in cardiac pacemaker cells
topic_facet Bioquímica
Coupled-clock system
Mathematical modeling
Pacemaker
description The sinoatrial node is the primary pacemaker that controls the heart rate under normal conditions. Although the heart rate was originally measured thousands of years ago, the mechanisms that control the spontaneous beating of the sinoatrial node (SAN) are still under debate. In the last century, SAN function was mostly investigated by electrophysiological tools. Therefore, not surprisingly, the major mechanisms that control SAN function were thought to be related only to membranal ionic modulations. Recent biophysical, biochemical and imaging techniques have shed new light on the role of intrinsic pacemaker mechanisms on SAN function. Specifically, the role of post-translational modification signaling on SAN function has been explored using numerical and experimental tools. We describe here the major breakthroughs related to these signaling mechanisms in SAN cells. We conclude that the recent findings are only the tip of the iceberg in the fascinating world of downstream post-translational modification signaling, and we point out future research directions that may increase our knowledge of pacemaker function.
format Articulo
Revision
author Yaniv, Yael
author_facet Yaniv, Yael
author_sort Yaniv, Yael
title The tango between pka and camkii signaling in cardiac pacemaker cells
title_short The tango between pka and camkii signaling in cardiac pacemaker cells
title_full The tango between pka and camkii signaling in cardiac pacemaker cells
title_fullStr The tango between pka and camkii signaling in cardiac pacemaker cells
title_full_unstemmed The tango between pka and camkii signaling in cardiac pacemaker cells
title_sort tango between pka and camkii signaling in cardiac pacemaker cells
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/127651
https://pmr.safisiol.org.ar/archive/id/90
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