Hepatocyte aquaporins in bile physiology and disease

Bile formation by hepatocytes is an osmotic secretory process resulting from the canalicular secretion of water in response to osmotic gradients created by the active transport of solutes, primarily bile salts, and other organic anions. Thus bile secretion would be ultimately dependent on the canali...

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Detalles Bibliográficos
Autores principales:	Marinelli, Raúl A., Marrone, Julieta, Soria, Leandro R.
Formato:	Articulo Revision
Lenguaje:	Inglés
Publicado:	2016
Materias:	Ciencias Médicas Aquaporin water channels Hepatocytes Bile secretion Cholestasis
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/127642 https://pmr.safisiol.org.ar/archive/id/82
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-127642
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Aquaporin water channels Hepatocytes Bile secretion Cholestasis
spellingShingle	Ciencias Médicas Aquaporin water channels Hepatocytes Bile secretion Cholestasis Marinelli, Raúl A. Marrone, Julieta Soria, Leandro R. Hepatocyte aquaporins in bile physiology and disease
topic_facet	Ciencias Médicas Aquaporin water channels Hepatocytes Bile secretion Cholestasis
description	Bile formation by hepatocytes is an osmotic secretory process resulting from the canalicular secretion of water in response to osmotic gradients created by the active transport of solutes, primarily bile salts, and other organic anions. Thus bile secretion would be ultimately dependent on the canalicular expression of bile salt and organic anion transporters as well as the osmotic water permeability of the canalicular plasma membrane domain, mainly determined by aquaporin-8 (AQP8) water channels. Compelling experimental evidence suggests that canalicular AQP8 facilitates the osmotically-coupled transport of solute and water during the formation of bile. Downregulation of AQP8-mediated hepatocyte canalicular water permeability is found in rat models of hepatocellular cholestasis suggesting that defective hepatocyte AQP8 expression is involved in the molecular mechanisms of bile secretory failure. The study of AQP function in liver has provided new insights into normal bile physiology and disease mechanisms, and may yield novel therapies to improve certain cholestatic conditions.
format	Articulo Revision
author	Marinelli, Raúl A. Marrone, Julieta Soria, Leandro R.
author_facet	Marinelli, Raúl A. Marrone, Julieta Soria, Leandro R.
author_sort	Marinelli, Raúl A.
title	Hepatocyte aquaporins in bile physiology and disease
title_short	Hepatocyte aquaporins in bile physiology and disease
title_full	Hepatocyte aquaporins in bile physiology and disease
title_fullStr	Hepatocyte aquaporins in bile physiology and disease
title_full_unstemmed	Hepatocyte aquaporins in bile physiology and disease
title_sort	hepatocyte aquaporins in bile physiology and disease
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/127642 https://pmr.safisiol.org.ar/archive/id/82
work_keys_str_mv	AT marinelliraula hepatocyteaquaporinsinbilephysiologyanddisease AT marronejulieta hepatocyteaquaporinsinbilephysiologyanddisease AT sorialeandror hepatocyteaquaporinsinbilephysiologyanddisease
bdutipo_str	Repositorios
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Hepatocyte aquaporins in bile physiology and disease

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