Localization and socialization: experimental insights into the functional architecture of IP₃ receptors

Inositol 1,4,5-trisphosphate (IP₃)-evoked Ca²⁺ signals display great spatiotemporal malleability. This malleability depends on diversity in both the cellular organization and in situ functionality of IP₃ receptors (IP₃Rs) that regulate Ca²⁺ release from the endoplasmic reticulum (ER). Recent experi...

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Detalles Bibliográficos
Autores principales: Diambra, Luis Aníbal, Marchant, Jonathan S.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Biología
Malleability
Ligands
Stochastic processes
Homeostasis
Antibody
Cell anatomy
Cell lines
Conformational dynamics
Chemical bonding
Proteins
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127307
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127307
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Malleability
Ligands
Stochastic processes
Homeostasis
Antibody
Cell anatomy
Cell lines
Conformational dynamics
Chemical bonding
Proteins
spellingShingle Biología
Malleability
Ligands
Stochastic processes
Homeostasis
Antibody
Cell anatomy
Cell lines
Conformational dynamics
Chemical bonding
Proteins
Diambra, Luis Aníbal
Marchant, Jonathan S.
Localization and socialization: experimental insights into the functional architecture of IP₃ receptors
topic_facet Biología
Malleability
Ligands
Stochastic processes
Homeostasis
Antibody
Cell anatomy
Cell lines
Conformational dynamics
Chemical bonding
Proteins
description Inositol 1,4,5-trisphosphate (IP₃)-evoked Ca²⁺ signals display great spatiotemporal malleability. This malleability depends on diversity in both the cellular organization and in situ functionality of IP₃ receptors (IP₃Rs) that regulate Ca²⁺ release from the endoplasmic reticulum (ER). Recent experimental data imply that these considerations are not independent, such that—as with other ion channels—the local organization of IP₃Rs impacts their functionality, and reciprocally IP₃R activity impacts their organization within native ER membranes. Here, we (i) review experimental data that lead to our understanding of the “functional architecture” of IP₃Rs within the ER, (ii) propose an updated terminology to span the organizational hierarchy of IP₃Rs observed in intact cells, and (iii) speculate on the physiological significance of IP₃R socialization in Ca²⁺ dynamics, and consequently the emerging need for modeling studies to move beyond gridded, planar, and static simulations of IP₃R clustering even over short experimental timescales.
format Articulo
Articulo
author Diambra, Luis Aníbal
Marchant, Jonathan S.
author_facet Diambra, Luis Aníbal
Marchant, Jonathan S.
author_sort Diambra, Luis Aníbal
title Localization and socialization: experimental insights into the functional architecture of IP₃ receptors
title_short Localization and socialization: experimental insights into the functional architecture of IP₃ receptors
title_full Localization and socialization: experimental insights into the functional architecture of IP₃ receptors
title_fullStr Localization and socialization: experimental insights into the functional architecture of IP₃ receptors
title_full_unstemmed Localization and socialization: experimental insights into the functional architecture of IP₃ receptors
title_sort localization and socialization: experimental insights into the functional architecture of ip₃ receptors
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/127307
work_keys_str_mv AT diambraluisanibal localizationandsocializationexperimentalinsightsintothefunctionalarchitectureofip3receptors
AT marchantjonathans localizationandsocializationexperimentalinsightsintothefunctionalarchitectureofip3receptors
bdutipo_str Repositorios
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