Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5

Toll-like receptors (TLR) detect pathogen-associated molecular patterns (PAMP) and play a crucial role in triggering immunity. Due to their large surfaces in direct contact with the environment, mucosal tissues are the major sites of PAMP-TLR signalling. How innate and adaptive immunity are triggere...

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Detalles Bibliográficos
Autores principales: Rumbo, Martín, Nempont, Clément, Kraehenbuhl, Jean-Pierre, Sirard, Jean-Claude
Formato: Articulo
Lenguaje:Inglés
Publicado: 2006
Materias:
Ciencias Exactas
Toll-like receptor
Flagellin
Innate immunity
Epithelium
Pathogenic bacteria
Commensal flora
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127275
https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2006.04.036
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127275
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Toll-like receptor
Flagellin
Innate immunity
Epithelium
Pathogenic bacteria
Commensal flora
spellingShingle Ciencias Exactas
Toll-like receptor
Flagellin
Innate immunity
Epithelium
Pathogenic bacteria
Commensal flora
Rumbo, Martín
Nempont, Clément
Kraehenbuhl, Jean-Pierre
Sirard, Jean-Claude
Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
topic_facet Ciencias Exactas
Toll-like receptor
Flagellin
Innate immunity
Epithelium
Pathogenic bacteria
Commensal flora
description Toll-like receptors (TLR) detect pathogen-associated molecular patterns (PAMP) and play a crucial role in triggering immunity. Due to their large surfaces in direct contact with the environment, mucosal tissues are the major sites of PAMP-TLR signalling. How innate and adaptive immunity are triggered through flagellin-TLR5 interaction is the main focus of the review. In view of recent reports on genetic polymorphism, we will summarize the impact of TLR5 on the susceptibility to mucosal infections and on various immuno-pathologies. Finally, the contribution of TLRs in the induction and maintenance of mucosal homeostasis and commensal discrimination is discussed.
format Articulo
Articulo
author Rumbo, Martín
Nempont, Clément
Kraehenbuhl, Jean-Pierre
Sirard, Jean-Claude
author_facet Rumbo, Martín
Nempont, Clément
Kraehenbuhl, Jean-Pierre
Sirard, Jean-Claude
author_sort Rumbo, Martín
title Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
title_short Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
title_full Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
title_fullStr Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
title_full_unstemmed Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
title_sort mucosal interplay among commensal and pathogenic bacteria : lessons from flagellin and toll-like receptor 5
publishDate 2006
url http://sedici.unlp.edu.ar/handle/10915/127275
https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2006.04.036
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