Cellular and molecular basis of progesterone-induced neuroprotection

Progesterone exerts several effects in the central nervous system not directly involved in reproduction or sex behavior. Non-reproductive effects are better observed under pathological conditions, and include stimulation of myelin formation, neurogenesis and neurosteroidogenesis, preserved mitochond...

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Detalles Bibliográficos
Autores principales: De Nicola, Alejandro F., Garay, Laura, Meyer, Maria, Labombarda, Florencia, González Deniselle, María Claudia
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2018
Materias:
Bioquímica
Progesterone
Neuroinflammation
Neurodegeneration
Neuroprotection
Progesterona
Neuroinflamación
Neurodegeneración
Neuroprotección
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127232
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127232
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Progesterone
Neuroinflammation
Neurodegeneration
Neuroprotection
Progesterona
Neuroinflamación
Neurodegeneración
Neuroprotección
spellingShingle Bioquímica
Progesterone
Neuroinflammation
Neurodegeneration
Neuroprotection
Progesterona
Neuroinflamación
Neurodegeneración
Neuroprotección
De Nicola, Alejandro F.
Garay, Laura
Meyer, Maria
Labombarda, Florencia
González Deniselle, María Claudia
Cellular and molecular basis of progesterone-induced neuroprotection
topic_facet Bioquímica
Progesterone
Neuroinflammation
Neurodegeneration
Neuroprotection
Progesterona
Neuroinflamación
Neurodegeneración
Neuroprotección
description Progesterone exerts several effects in the central nervous system not directly involved in reproduction or sex behavior. Non-reproductive effects are better observed under pathological conditions, and include stimulation of myelin formation, neurogenesis and neurosteroidogenesis, preserved mitochondrial function, neuroprotection, anti-inflammatory effects, decreased glutamate excitotoxicity, and regulation of mood, memory and cognition. In addition, the progesterone reduced derivative allopregnanolone shows anxiolytic, sedative and anesthetic properties after binding to GABAa receptors. In the present report we provide examples of [1] progesterone effects on the local synthesis of steroids (“neurosteroids”) in a demyelination model, [2] the requirement of the classical progesterone receptor for the antiinflammatory effects in mice with spinal cord injury, and [3] the protective role of progesterone and allopregnanolone in a mouse model of neurodegeneration. In conclusion, the beneficial effects observed in different experimental paradigms support the versatile properties of progesterone in animal models of central nervous system disorders.
format Articulo
Revision
author De Nicola, Alejandro F.
Garay, Laura
Meyer, Maria
Labombarda, Florencia
González Deniselle, María Claudia
author_facet De Nicola, Alejandro F.
Garay, Laura
Meyer, Maria
Labombarda, Florencia
González Deniselle, María Claudia
author_sort De Nicola, Alejandro F.
title Cellular and molecular basis of progesterone-induced neuroprotection
title_short Cellular and molecular basis of progesterone-induced neuroprotection
title_full Cellular and molecular basis of progesterone-induced neuroprotection
title_fullStr Cellular and molecular basis of progesterone-induced neuroprotection
title_full_unstemmed Cellular and molecular basis of progesterone-induced neuroprotection
title_sort cellular and molecular basis of progesterone-induced neuroprotection
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/127232
work_keys_str_mv AT denicolaalejandrof cellularandmolecularbasisofprogesteroneinducedneuroprotection
AT garaylaura cellularandmolecularbasisofprogesteroneinducedneuroprotection
AT meyermaria cellularandmolecularbasisofprogesteroneinducedneuroprotection
AT labombardaflorencia cellularandmolecularbasisofprogesteroneinducedneuroprotection
AT gonzalezdenisellemariaclaudia cellularandmolecularbasisofprogesteroneinducedneuroprotection
bdutipo_str Repositorios
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