Microtubules and mitochondria nanotunnels

Mitochondrial function strictly depends on mitochondrial structure, location and dynamics. Mitochondria and cytoskeleton interaction is crucial for normal mitochondrial morphology distribution and motility. In cardiac muscle, microtubules sustain muscle contraction and mitochondria disposition; the...

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Detalles Bibliográficos
Autor principal: Lavorato, Manuela
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2018
Materias:
Biología
Mitochondria nanotunnels
Microtubules
Cardiac muscle
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127230
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127230
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Mitochondria nanotunnels
Microtubules
Cardiac muscle
spellingShingle Biología
Mitochondria nanotunnels
Microtubules
Cardiac muscle
Lavorato, Manuela
Microtubules and mitochondria nanotunnels
topic_facet Biología
Mitochondria nanotunnels
Microtubules
Cardiac muscle
description Mitochondrial function strictly depends on mitochondrial structure, location and dynamics. Mitochondria and cytoskeleton interaction is crucial for normal mitochondrial morphology distribution and motility. In cardiac muscle, microtubules sustain muscle contraction and mitochondria disposition; the latter is crucial for localized uptake of calcium (Ca2+) and consequentially energy production needed for cardiac function. Few studies have been conducted on understanding mitochondria and microtubules interaction in cardiomyocytes. In cardiac muscle, recent studies have shown that cardiac mitochondria do not need to migrate to communicate with each other, but they can extend protrusions called nanotunnels to reach and communicate with other mitochondria in long-distance. This process does not involve mitochondria movement, but possibly involves a pulling action along microtubules. The association of mitochondria nanotunnels and microtubules have been identified using 2D and 3D electron microscopy [1]. These new findings highlight the need to investigate the action of microtubules on cardiac mitochondria and its effect on mitochondria dynamics and cardiac function.
format Articulo
Revision
author Lavorato, Manuela
author_facet Lavorato, Manuela
author_sort Lavorato, Manuela
title Microtubules and mitochondria nanotunnels
title_short Microtubules and mitochondria nanotunnels
title_full Microtubules and mitochondria nanotunnels
title_fullStr Microtubules and mitochondria nanotunnels
title_full_unstemmed Microtubules and mitochondria nanotunnels
title_sort microtubules and mitochondria nanotunnels
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/127230
work_keys_str_mv AT lavoratomanuela microtubulesandmitochondriananotunnels
bdutipo_str Repositorios
_version_ 1764820451476897792

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