The immediately releasable pool of secretory vesicles in adrenal chromaffin cells

The exocytosis of hormone-filled vesicles in adrenal chromaffin cells is triggered by localized Ca²⁺ gradients that develops after the activation of voltage-dependent Ca²⁺ channels. To reach the fusion competent state the vesicles go through a variety of maturation steps, including the mobilization...

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Detalles Bibliográficos
Autor principal: Marengo, Fernando D.
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2018
Materias:
Biología
Exocytosis
P/Q channels
Endocytosis
Calcium
Exocitosis
Canales P/Q
Endocitosis
Calcio
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127228
https://pmr.safisiol.org.ar/uploadsarchivos/vol_11_n_4_marengo_dw.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127228
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Exocytosis
P/Q channels
Endocytosis
Calcium
Exocitosis
Canales P/Q
Endocitosis
Calcio
spellingShingle Biología
Exocytosis
P/Q channels
Endocytosis
Calcium
Exocitosis
Canales P/Q
Endocitosis
Calcio
Marengo, Fernando D.
The immediately releasable pool of secretory vesicles in adrenal chromaffin cells
topic_facet Biología
Exocytosis
P/Q channels
Endocytosis
Calcium
Exocitosis
Canales P/Q
Endocitosis
Calcio
description The exocytosis of hormone-filled vesicles in adrenal chromaffin cells is triggered by localized Ca²⁺ gradients that develops after the activation of voltage-dependent Ca²⁺ channels. To reach the fusion competent state the vesicles go through a variety of maturation steps, including the mobilization through the cytoskeleton, the docking to membrane, and the priming of the exocytotic molecular machinery. However, the fusion readiness of vesicles will also depend on their proximity to the Ca²⁺ source. The immediately releasable pool is a small group of ready–to-fuse vesicles, whose fusion is tightly coupled to Ca²⁺ entry through channels. Recent work indicates that such a coupling is not produced by a random distribution between parts, but is the result of a specific interaction of secretory vesicles with P/Q-type Ca²⁺ channels. The immediately releasable pool is able to sustain with high efficiency the secretion triggered by brief depolarizations applied at low frequencies, like action potentials at basal conditions in adrenal chromaffin cells.
format Articulo
Revision
author Marengo, Fernando D.
author_facet Marengo, Fernando D.
author_sort Marengo, Fernando D.
title The immediately releasable pool of secretory vesicles in adrenal chromaffin cells
title_short The immediately releasable pool of secretory vesicles in adrenal chromaffin cells
title_full The immediately releasable pool of secretory vesicles in adrenal chromaffin cells
title_fullStr The immediately releasable pool of secretory vesicles in adrenal chromaffin cells
title_full_unstemmed The immediately releasable pool of secretory vesicles in adrenal chromaffin cells
title_sort immediately releasable pool of secretory vesicles in adrenal chromaffin cells
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/127228
https://pmr.safisiol.org.ar/uploadsarchivos/vol_11_n_4_marengo_dw.pdf
work_keys_str_mv AT marengofernandod theimmediatelyreleasablepoolofsecretoryvesiclesinadrenalchromaffincells
AT marengofernandod immediatelyreleasablepoolofsecretoryvesiclesinadrenalchromaffincells
bdutipo_str Repositorios
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